ArticleThe Biochemical journal1992
Isolation and characterization of the complement-inhibiting protein CD59 antigen from platelet membranes.
Article in The Biochemical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Activated Platelets Express GPI-Anchored Fibrocystin-L (PKHD1L1), from Granules, Absent or Deficient in Paroxysmal Nocturnal Hemoglobinuria.International journal of molecular sciences · 2026Article
- CD59 gene: 143 haplotypes of 22,718 nucleotides length by computational phasing in 113 individuals from different ethnicities.Transfusion · 2024Article
- The Human Platelet as an Innate Immune Cell: Interactions Between Activated Platelets and the Complement System.Frontiers in immunology · 2019Review
- Complement regulatory proteins in kidneys of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.Clinical and experimental immunology · 2018Article
- Osteoarthritis and the Complement Cascade.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2018Review
- Absence of CD59 in Guinea Pigs: Analysis of theJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Identification of a novel mode of complement activation on stimulated platelets mediated by properdin and C3(H2O).Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Role of platelets in neuroinflammation: a wide-angle perspective.Journal of neuroinflammation · 2010Review
- Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Characterization in vitro and in vivo of the pig analogue of human CD59 using new monoclonal antibodies.Immunology · 1998Article
- Membrane proteins that protect against complement lysis.Springer seminars in immunopathology · 1994Review
- Platelet activation releases megakaryocyte-synthesized apolipoprotein J, a highly abundant protein in atheromatous lesions.The American journal of pathology · 1993Article
- The sheep analogue of human CD59: purification and characterization of its complement inhibitory activity.Immunology · 1993Article
- Membrane defence against complement lysis: the structure and biological properties of CD59.Immunologic research · 1993Review
- Isolation and characterization of a membrane protein from rat erythrocytes which inhibits lysis by the membrane attack complex of rat complement.The Biochemical journal · 1992Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Several groups have recently described the isolation of a 20 kDa membrane-attack-complex (MAC)-inhibiting protein, termed 'CD59 antigen', from human erythrocyte membranes. Antibodies raised against erythrocyte CD59 antigen detect antigen on the surface of many other cell types, and in some of these cells the antigen has been shown to have a molecular mass similar to that of the erythrocyte protein and to confer resistance to lysis by the MAC. A platelet-membrane form of CD59 antigen has been described and reported to be much larger than the erythrocyte protein. Here I report the isolation of CD59 antigen from platelet membranes and its molecular and functional characterization. The platelet protein is not significantly larger than the erythrocyte form and possesses similar MAC-inhibiting activity. Platelet CD59 antigen is anchored to the membrane via a glycosyl-phosphatidylinositol link, and consequently it is suggested that deficiency of this protein might be responsible for the increased thrombotic tendency observed in paroxysmal nocturnal haemoglobinuria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.