ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1992
An actin-associated protein present in the microtubule organizing center and the growth cones of PC-12 cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
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- New structural and functional contexts of the Dx[DN]xDG linear motif: insights into evolution of calcium-binding proteins.PloS one · 2011Article
- The yin-yang of dendrite morphology: unity of actin and microtubules.Molecular neurobiology · 2008Review
- Actin dynamics in platelets.International review of cytology · 2002Review
- Motility-related proteins as markers for head and neck squamous cell cancer.The Laryngoscope · 2001Article
- 2E4/Kaptin (KPTN)--a candidate gene for the hearing loss locus, DFNA4.Annals of human genetics · 2000Article
- 2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear.European journal of cell biology · 1999Article
- Association of actin filaments with axonal microtubule tracts.Journal of neurocytology · 1999Article
- Suppression of KIF2 in PC12 cells alters the distribution of a growth cone nonsynaptic membrane receptor and inhibits neurite extension.The Journal of cell biology · 1997Article
- Expression and distribution of IGF-1 receptors containing a beta-subunit variant (betagc) in developing neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research · 1995Article
- Cytoskeletal domains in the activated platelet.Cell motility and the cytoskeleton · 1995Article
- Distribution of Xrel in the early Xenopus embryo: a cytoplasmic and nuclear gradient.European journal of cell biology · 1994Article
- Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity.Molecular biology of the cell · 1993Article
- Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ.The Journal of cell biology · 1993Article
- Role of actin polymerization in cell locomotion: molecules and models.American journal of respiratory cell and molecular biology · 1993Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The pathfinding ability of the growth cone depends upon the integrity of a dynamic actin filament network. However, although a number of actin-binding proteins have been found in growth cones, it is not known how these proteins come to be concentrated there or how they might interact to produce these important actin filaments. In this report, an actin-associated protein recognized by the monoclonal antibody 2E4 is demonstrated to be present in PC-12 cells. In undifferentiated cells, this protein is present in an apparently inactive state in a perinuclear location that corresponds to that of the microtubule organizing center and not of the Golgi apparatus. Conversely, after NGF-induced differentiation, the antigen is found enriched in the neurite and growth cone and disappears from the perinuclear position. This disappearance is directly proportional to the length of the neurite. The antigen-antibody complex binds the ends of actin filaments in vitro in an ATP-sensitive manner, and the antibody stains the outermost edge of the actin filament ruffle in the leading edge of migrating fibroblasts. Hence, it is possibly involved in the membrane-associated polymerization of actin filaments such as that observed in growth cones.
Indexed as
Identifiers
1372044PMC3376081W2100624617What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.