ArticleThe EMBO journal1992
Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 108 citations in OpenAlex.
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- Calmodulin and Its Interactive Proteins Participate in Regulating the Explosive Growth ofInternational journal of molecular sciences · 2021Article
- Maternal and fetal thyroid dysfunction following porcine reproductive and respiratory syndrome virus2 infection.Veterinary research · 2020Article
- Chronic ethanol increases calcium/calmodulin-dependent protein kinaseIIδ gene expression and decreases monoamine oxidase amount in rat heart muscles: Rescue effect of Zingiber officinale (ginger) extract.Anatolian journal of cardiology · 2018Article
- A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.Cellular signalling · 2015Article
- Kv3.4 potassium channel-mediated electrosignaling controls cell cycle and survival of irradiated leukemia cells.Pflugers Archiv : European journal of physiology · 2013Article
- Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis.Endocrinology · 2012Article
- STIM2 Contributes to Enhanced Store-operated Ca Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension.Pulmonary circulation · 2011Article
- Ca(2+) signaling, genes and the cell cycle.Cell calcium · 2010Review
- Regulation of CaMKII in vivo: the importance of targeting and the intracellular microenvironment.Neurochemical research · 2009Review
- CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells.The Journal of clinical investigation · 2007Article
- Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.Molecular biology of the cell · 2003Article
- Magnitude of the CREB-dependent transcriptional response is determined by the strength of the interaction between the kinase-inducible domain of CREB and the KIX domain of CREB-binding protein.Molecular and cellular biology · 2000Article
- Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18.Molecular and cellular biology · 1997Article
- Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases.Cell proliferation · 1997Article
- Overexpression of Ca2+/calmodulin-dependent protein kinase II in PC12 cells alters cell growth, morphology, and nerve growth factor-induced differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.Molecular biology of the cell · 1996Article
- UV irradiation-induced apoptosis leads to activation of a 36-kDa myelin basic protein kinase in HL-60 cells.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Calcium/calmodulin dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase. We have created a calcium/calmodulin independent form of this enzyme by truncation. Expression of this enzyme fragment in a rabbit reticulocyte lysate yields a constitutive enzyme with specific activity similar to the activated native enzyme. We have established mammalian cell lines that transiently express this constitutive enzyme using the glucocorticoid-inducible mouse mammary tumor virus long terminal repeat. The transient increase in kinase activity results in a complete cessation of cell cycle progression. This block develops as a consequence of a specific arrest of the cell cycle in G2. During the block, increases in histone H1 kinase activity present in p13 beads or anti-cdc2 immunoprecipitates are seen in parallel with the accumulation of cells at G2, arguing that the arrest is not due to a failure to activate cdc2 as a histone H1 kinase. These results suggest that other changes in serine/threonine protein phosphorylation besides those involved in activation of cdc2 as a histone H1 kinase may be necessary for proper G2-M transition.
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