ArticleThe EMBO journal1992
CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 164 citations in OpenAlex.
- The histone methyltransferase Setd2 is indispensable for V(D)J recombination.Nature communications · 2019Article
- Histone methylation and V(D)J recombination.International journal of hematology · 2014Review
- Epigenetic control of recombination in the immune system.Seminars in immunology · 2010Review
- Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Allelic exclusion of immunoglobulin genes: models and mechanisms.Immunological reviews · 2010Review
- Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.Molecular cell · 2008Article
- Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Advances in immunology · 2008Review
- Type 2 NF1 deletions are highly unusual by virtue of the absence of nonallelic homologous recombination hotspots and an apparent preference for female mitotic recombination.American journal of human genetics · 2007Article
- Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery.Nucleic acids research · 2004Article
- A multistep mechanism for the activation of rearrangement in the immune system.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene.Oncogene · 2003Article
- Differential accessibility at the kappa chain locus plays a role in allelic exclusion.The EMBO journal · 2002Article
- DNA methylation has a local effect on transcription and histone acetylation.Molecular and cellular biology · 2002Article
- DNA methylation, methyltransferases, and cancer.Oncogene · 2001Review
- Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.The Journal of experimental medicine · 2001Article
- Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination.The Journal of experimental medicine · 2000Article
- V(D)J recombination is not activated by demethylation of the kappa locus.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b.Molecular and cellular biology · 1999Article
- Chromatin remodeling directly activates V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The physical parameters controlling the accessibility of antigen receptor loci to the V(D)J recombination activity are unknown. We have used minichromosome substrates to study the role that CpG methylation might play in controlling V(D)J recombination site accessibility. We find that CpG methylation decreases the V(D)J recombination of these substrates more than 100-fold. The decrease correlates with a considerable increase in resistance to endonuclease digestion of the methylated minichromosome DNA. The minichromosomes acquire resistance to both the intracellular V(D)J recombinase and exogenous endonuclease only after DNA replication. Therefore, CpG methylation specifies a chromatin structure that, upon DNA replication, is resistant to eukaryotic site-specific recombination. These findings are important to V(D)J recombination as well as to the chromatin assembly of methylated DNA during replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.