ArticleClinical and experimental immunology1992
Enhancement of the antigen-presenting function of monocytes by cholesterol: possible relevance to inflammatory mechanisms in extrinsic allergic alveolitis and atherosclerosis.
Article in Clinical and experimental immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Pooled it
- The Oxidative Stress and Inflammatory Metabolic Pathways of Some Environmental Toxicants Inflicting Human Disorders.Toxics · 2026Review
- The impact ofFrontiers in immunology · 2024Review
- Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia.Microorganisms · 2021Review
- Significance of preoperative nutritional status as a predictor for short-term and long-term outcomes of patients undergoing surgery for stage IV colorectal cancer.Langenbeck's archives of surgery · 2021Article
- The preoperative controlling nutritional status (CONUT) score is an independent prognostic marker for pancreatic ductal adenocarcinoma.Updates in surgery · 2021Article
- Hyperglycemia and dyslipidemia: Reduced HLA-DR expression in monocyte subpopulations from diabetes patients.Human immunology · 2021Observational
- Development of a New Recurrence-Free Survival Prediction Nomogram for Patients with Primary Non-Muscle-Invasive Bladder Cancer Based on Preoperative Controlling Nutritional Status Score.Cancer management and research · 2021Article
- Article
- Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases.Endocrine reviews · 2012Review
- Preoperative Total Serum Cholesterol and Patients' Survival in Resected Nonsmall Cell Lung Cancer.Lung cancer international · 2012Article
- Human visceral leishmaniasis: decrease in serum cholesterol as a function of splenic parasite load.Annals of tropical medicine and parasitology · 2011Article
- Designing therapies against experimental visceral leishmaniasis by modulating the membrane fluidity of antigen-presenting cells.Infection and immunity · 2009Article
- Preoperative total serum cholesterol as a prognostic factor for survival in patients with resectable non-small-cell lung cancer.Wiener klinische Wochenschrift · 2009Article
- Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Monocyte matrix metalloproteinase production in Type 2 diabetes and controls--a cross sectional study.Cardiovascular diabetology · 2003Article
- Review
- Stimulation with a monoclonal antibody (mAb4E4) of scavenger receptor-mediated uptake of chemically modified low density lipoproteins by THP-1-derived macrophages enhances foam cell generation.The Journal of clinical investigation · 1994Article
- The CONUT score is prognostic in esophageal cancer treated with chemoradiotherapy.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extrinsic allergic alveolitis (EAA) (synonym: hypersensitivity pneumonitis) is a hypersensitivity lung disease characterized by lymphocytic infiltrates in the pulmonary interstitial tissues. We have previously reported that the numbers of lymphocytes in bronchoalveolar lavage (BAL) samples in this disease correlate with levels of cholesterol and neutral lipid-laden 'foamy' macrophages. We have also reported that the macrophages express an increased density of MHC class II antigens (in particular HLA-DQ) which are known to be essential for antigen recognition by T lymphocytes. The aim of the present study was to explore whether cholesterol is capable of enhancing the antigen-presenting function of mononuclear phagocytes by modulating the expression of HLA-D region products. Incubation of purified monocytes from healthy volunteers with cholesterol in serum-free medium induced a significant increase in both the percentages of monocytes expressing HLA-DQ (P less than 0.02) and in the intensity of expression of the three HLA-D sub-region products, HLA-DQ, -DP and -DR (P less than 0.02, less than 0.01, less than 0.05, respectively). The cholesterol pre-incubated monocytes also exhibited enhanced antigen-presenting function (P less than 0.05), compared with controls pre-incubated without cholesterol. These findings indicate that increases in cholesterol in the extracellular milieu may augment antigen presentation by modulating the expression of HLA-D region products on antigen-presenting cells. Apart from EAA, this observation may also have relevance to inflammatory mechanisms in atherosclerosis, where 'foamy' macrophages also occur in association with hypercholesterolaemia.
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