ArticleClinical and experimental immunology1992
Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat shock protein: specificity and mechanism.
Article in Clinical and experimental immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Role of heat shock proteins in diseases and their therapeutic potential.Indian journal of microbiology · 2011Article
- Role of heat shock proteins in protection from and pathogenesis of infectious diseases.Clinical microbiology reviews · 1999Review
- Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis.The Journal of experimental medicine · 1995Article
- PPD and hsp65 induced monoarthritis initiates spontaneous recurrent flares in Lewis rats.Annals of the rheumatic diseases · 1995Article
- The roles of the hypothalamus and the gastrointestinal tract in the prevention of inflammatory autoimmune disease.Clinical and experimental immunology · 1994Review
- High-density proteoglycan induces specific suppression of adjuvant-induced arthritis in rats.Clinical and experimental immunology · 1994Article
- Sequence and diversity of rat T-cell receptor alpha-chain-encoding genes.Immunogenetics · 1994Article
- Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.Infection and immunity · 1993Article
- Characterization of a stress protein from group B Neisseria meningitidis.Journal of bacteriology · 1993Article
- Heat shock proteins in autoimmune disease. From causative antigen to specific therapy?Experientia · 1992Review
- The humoral immune response to heat shock proteins.Experientia · 1992Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous study we have shown that Lewis rats were completely protected from adjuvant arthritis by pretreatment with a nonapeptide (residues 180-188) of the 65-kD mycobacterial heat shock protein. Here we address questions of specificity and mechanism(s) of protection. We demonstrate that complete protection against adjuvant arthritis can only be achieved by pre-immunization with the nonapeptide, while pretreatment with either the octapeptide (residues 181-188) of the 65-kD heat shock protein or unrelated immunogenic peptides failed to affect adjuvant arthritis. Interestingly, pretreatment with the nonapeptide of the 65-kD heat shock protein did not protect Lewis rats from type II collagen-induced arthritis. These results demonstrate that protection is both epitope and disease specific. Co-injection of the nonapeptide with mycobacterial antigen even at a weight ratio of 5:1 (nonapeptide:mycobacteria) failed to influence the disease, suggesting that the role of the nonapeptide is not as a 'blocking peptide'. T cells from rats immunized with nonapeptide respond to the nonapeptide as well as to mycobacteria in vitro, and adoptively transfer protection to naive recipients. The data indicate that the nonapeptide-induced protection may result from a T cell-mediated specific suppression.
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