ArticleThe Journal of experimental medicine1992
The human fetal omentum: a site of B cell generation.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 126 citations in OpenAlex.
- Article
- Characteristics and clinical significance of immune cells in omental milky spots of patients with gastric cancer.Frontiers in immunology · 2025Article
- Robotic omentectomy in gynecologic oncology: surgical anatomy, indications, and a technical approach.Journal of robotic surgery · 2023Review
- Single-cell genomics identifies distinct B1 cell developmental pathways and reveals aging-related changes in the B-cell receptor repertoire.Cell & bioscience · 2022Article
- Glycan Reactive Natural Antibodies and Viral Immunity.Viral immunology · 2020Review
- The Greater Omentum-A Vibrant and Enigmatic Immunologic Organ Involved in Injury and Infection Resolution.Shock (Augusta, Ga.) · 2020Review
- Epigenetic Therapy as a Putative Molecular Target to Modulate B Cell Biology and Behavior in the Context of Immunological Disorders.Journal of immunology research · 2020Review
- Relevance of the Materno-Fetal Interface for the Induction of Antigen-Specific Immune Tolerance.Frontiers in immunology · 2020Review
- Omentum a powerful biological source in regenerative surgery.Regenerative therapy · 2019Review
- The immunophenotype of amniotic fluid leukocytes in normal and complicated pregnancies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Article
- Immunological Functions of the Omentum.Trends in immunology · 2017Review
- From Immunologically Archaic to Neoteric Glycovaccines.Vaccines · 2017Review
- Article
- B-1 B cell development in the fetus and adult.Immunity · 2012Review
- Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection.PloS one · 2012Article
- The Long and the Short of it: Gene and Environment Interactions During Early Cortical Development and Consequences for Long-Term Neurological Disease.Frontiers in psychiatry · 2012Article
- Review
- Adaptive immunity and adipose tissue biology.Trends in immunology · 2010Review
- Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens.Immunity · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The fetal mouse omentum has been shown to be a source of precursors that exclusively reconstitutes Ly1+ B cells and the closely related Ly1- sister population, but not conventional B cells or T cells. We have extended these studies to compare B cell development in the human fetal omentum, liver, and spleen, and to demonstrate that the pro/pre-B cell compartment (CD24+, sIgM-) is detected in the omentum and liver but not spleen as early as 8 wk of gestation. From 8 to 12 wk of gestation, the proportions of IgM+ cells that were pre-B cells (cIgM+/sIgM-) in the omentum and liver were 53 +/- 15% and 45 +/- 13%, respectively, and IgM+ cells were not detectable in the spleen. After 12 wk, the percentage of pre-B cells was unchanged in the fetal liver (41 +/- 10%) but decreased significantly in the omentum (25 +/- 14%); pre-B cells were now detected in the spleen but at much lower percentages (2 +/- 3%) than either the omentum or liver. The nuclear enzyme, Tdt, was detected in approximately 25% of the CD24+ cells in the omentum and liver during the 8-12-wk time period, however, Tdt+ cells were not detected in the spleen. Approximately 40% of the mature B cells found in the omentum and spleen were CD5+ compared with only 20% in the liver. These results demonstrate that the fetal omentum, like the fetal liver and bone marrow, is a primary site of B cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.