ArticleDevelopment genes and evolution2003
Molecular cloning and developmental expression of two Chloride Intracellular Channel (CLIC) genes in Xenopus laevis.
Article in Development genes and evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Identification and Analysis of Long Non-coding RNAs inFrontiers in physiology · 2021Article
- Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range.Oncotarget · 2014Article
- CLIC4 regulates TGF-β-dependent myofibroblast differentiation to produce a cancer stroma.Oncogene · 2014Article
- TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.Nature cell biology · 2009Article
- Redox regulation of CLIC1 by cysteine residues associated with the putative channel pore.Biophysical journal · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
CLIC proteins are components or regulators of novel intracellular anion channels in mammalian cells, and previous studies have suggested that human nuclear membrane-associated CLIC1 and mouse inner mitochondrial membrane CLIC4 are involved in cell division and apoptosis. We have isolated Xenopus homologues of CLIC1 and CLIC4 and shown them to be well conserved during chordate evolution, but poorly conserved in invertebrates. Consistent with fundamental cellular roles, Xenopus CLIC genes are expressed at every stage of embryonic development. Expression is localised to mesodermal and ectodermal tissues, with particularly marked expression of xCLIC4 in the developing nervous system. This is the first description of non-mammalian CLIC expression, and use of Xenopus laevis as a model organism may provide insights into the role of CLIC-associated ion channels in animal development.
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