ArticleDevelopment genes and evolution2003
Evolution of echinoderms may not have required modification of the ancestral deuterostome HOX gene cluster: first report of PG4 and PG5 Hox orthologues in echinoderms.
Article in Development genes and evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Phylogenomic analysis of echinoderm class relationships supports Asterozoa.Proceedings. Biological sciences · 2014Article
- Oral-aboral identity displayed in the expression of HpHox3 and HpHox11/13 in the adult rudiment of the sea urchin Holopneustes purpurescens.Development genes and evolution · 2014Article
- Article
- Evolution of Hox gene clusters in deuterostomes.BMC developmental biology · 2013Review
- Article
- Identical genomic organization of two hemichordate hox clusters.Current biology : CB · 2012Article
- Current Status of Echinoderm Genome Analysis - What do we Know?Current genomics · 2012Article
- Evolution of invertebrate deuterostomes and Hox/ParaHox genes.Genomics, proteomics & bioinformatics · 2011Review
- Expression of Hox4 during development of the pentamerous juvenile sea star, Parvulastra exigua.Development genes and evolution · 2009Article
- The Hox8 of the hemichordate Balanoglossus misakiensis.Development genes and evolution · 2009Article
- Hox genes are not always Colinear.International journal of biological sciences · 2006Review
- Engrailed is expressed in larval development and in the radial nervous system of Patiriella sea stars.Development genes and evolution · 2005Article
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Authors and funding
5 authors.
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Abstract
Is the extreme derivation of the echinoderm body plan reflected in a derived echinoderm Hox genotype? Building on previous work, we exploited the sequence conservation of the homeobox to isolate putative orthologues of several Hox genes from two asteroid echinoderms. The 5-peptide motif (LPNTK) diagnostic of PG4 Hox genes was identified immediately downstream of one of the partial homeodomains from Patiriella exigua. This constitutes the first unequivocal report of a PG4 Hox gene orthologue from an echinoderm. Subsequent screenings identified genes of both PG4 and PG4/5 in Asterias rubens. Although in echinoids only a single gene (PG4/5) occupies these two contiguous cluster positions, we conclude that the ancestral echinoderm must have had the complete deuterostome suite of medial Hox genes, including orthologues of both PG4 and PG4/5 (=PG5). The reported absence of PG4 in the HOX cluster of echinoids is therefore a derived state, and the ancestral echinoderm probably had a HOX cluster not dissimilar to that of other deuterostomes. Modification of the ancestral deuterostome Hox genotype may not have been required for evolution of the highly derived echinoderm body plan.
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