ArticleEuropean biophysics journal : EBJ2004
Elastic properties of the red blood cell membrane that determine echinocyte deformability.
Article in European biophysics journal : EBJ, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Effective cell membrane tension protects red blood cells against malaria invasion.PLoS computational biology · 2023Article
- Thermo-Mechanical Fluid-Structure Interaction Numerical Modelling and Experimental Validation of MEMS Electrothermal Actuators for Aqueous Biomedical Applications.Micromachines · 2023Article
- Structural Configuration of Blood Cell Membranes Determines Their Nonlinear Deformation Properties.BioMed research international · 2022Article
- Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion.Lab on a chip · 2021Article
- Deformability of Stored Red Blood Cells.Frontiers in physiology · 2021Review
- Non-uniform distribution of myosin-mediated forces governs red blood cell membrane curvature through tension modulation.PLoS computational biology · 2020Article
- A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies.PloS one · 2019Article
- A novel strain energy relationship for red blood cell membrane skeleton based on spectrin stiffness and its application to micropipette deformation.Biomechanics and modeling in mechanobiology · 2016Article
- Modeling the Behavior of Red Blood Cells within the Caudal Vein Plexus of Zebrafish.Frontiers in physiology · 2016Article
- Stress-free state of the red blood cell membrane and the deformation of its skeleton.Cellular & molecular biology letters · 2012Article
- Red blood cell shape and deformability in the context of the functional evolution of its membrane structure.Cellular & molecular biology letters · 2012Review
- Modeling the flow of dense suspensions of deformable particles in three dimensions.Physical review. E, Statistical, nonlinear, and soft matter physics · 2007Article
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4 authors.
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Abstract
The natural biconcave shape of red blood cells (RBC) may be altered by injury or environmental conditions into a spiculated form (echinocyte). An analysis is presented of the effect of such a transformation on the resistance of RBC to entry into capillary sized cylindrical tubes. The analysis accounts for the elasticity of the membrane skeleton in dilation and shear, and the local and nonlocal resistance of the bilayer to bending, the latter corresponding to different area strains in the two leaflets of the bilayer. The shape transformation is assumed to be driven by the equilibrium area difference (delta A(0), the difference between the equilibrium areas of the bilayer leaflets), which also affects the energy of deformation. The cell shape is approximated by a parametric model. Shape parameters, skeleton shear deformation, and the skeleton density of deformed membrane relative to the skeleton density of undeformed membrane are obtained by minimization of the corresponding thermodynamic potential. Experimentally, delta A(0) is modified and the corresponding discocyte-echinocyte shape transition obtained by high-pressure aspiration into a narrow pipette, and the deformability of the resulting echinocyte is examined by whole cell aspiration into a larger pipette. We conclude that the deformability of the echinocyte can be accounted for by the mechanical behavior of the normal RBC membrane, where the equilibrium area difference delta A(0) is modified.
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