ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2003
High content of polyunsaturated fatty acids in muscle phospholipids of a fast runner, the European brown hare (Lepus europaeus).
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Mitochondrial membrane remodeling during heat acclimation in Mongolian gerbils.Marine life science & technology · 2025Article
- The Fatty Acid Content, Health Lipid Indices, and Instrumental, Histological, and Sensory Quality of Hare Meat (Foods (Basel, Switzerland) · 2025Article
- Effects of Sex and Hunting Season on Carcass and Meat Quality Characteristics of the Brown Hare (Foods (Basel, Switzerland) · 2023Article
- Fatty acid composition of birds and game hunted by the Eastern James Bay Cree people of Québec.International journal of circumpolar health · 2016Article
- Activity of Selected Antioxidant Enzymes, Selenium Content and Fatty Acid Composition in the Liver of the Brown Hare (Lepus europaeus L.) in Relation to the Season of the Year.Biological trace element research · 2015Article
- Healthy n-6/n-3 fatty acid composition from five European game meat species remains after cooking.BMC research notes · 2015Article
- The European Hare (Lepus europaeus): A Picky Herbivore Searching for Plant Parts Rich in Fat.PloS one · 2015Article
- Article
- Phospholipid composition and longevity: lessons from Ames dwarf mice.Age (Dordrecht, Netherlands) · 2013Article
- A functional nexus between photoperiod acclimation, torpor expression and somatic fatty acid composition in a heterothermic mammal.PloS one · 2013Article
- Fatty Acid use in Diving Mammals: More than Merely Fuel.Frontiers in physiology · 2012Article
- Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.PloS one · 2011Article
- Feeding into old age: long-term effects of dietary fatty acid supplementation on tissue composition and life span in mice.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- Photoperiod affects daily torpor and tissue fatty acid composition in deer mice.Die Naturwissenschaften · 2007Article
- Running speed in mammals increases with muscle n-6 polyunsaturated fatty acid content.PloS one · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate both seasonal changes and possible intracorporal gradients of phospholipid fatty acid composition, skeletal muscles ( n=124), hearts ( n=27), and livers ( n=34) from free-living brown hares (Lepus europaeus) were analyzed. Phospholipids from both skeletal muscles and heart had a high degree of unsaturation with 66.8+/-0.63% and 65.7+/-0.5% polyunsaturated fatty acids, respectively. This is the highest proportion of polyunsaturated fatty acids reported in any mammalian tissue. Polyunsaturated fatty acid content in skeletal muscles was 2.3% greater in winter compared to summer (F(1,106)=17.7; P=0.0001), which may reflect thermoregulatory adjustments. Arachidonate (C20:4n-6) showed the greatest seasonal increase (+2.5%; F=7.95; P=0.0057). However, there were no pronounced differences in polyunsaturated fatty acid content between skeletal muscles from different locations in the body (m. iliopsoas, m. longissimus dorsi and m. vastus). Total muscle phospholipid polyunsaturated fatty acid content was correlated with polyunsaturated fatty acid content in triacyglycerols from perirenal white adipose tissue depots ( r(2)=0.61; P=0.004). Polyunsaturated fatty acids were enriched in muscle phospholipids (56.8-73.6%), compared to white adipose tissue lipids (20.9-61.2%), and liver phospholipids (25.1-54.2%). We suggest that the high degree of muscle membrane unsaturation is related to hare-specific traits, such as a high maximum running speed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.