ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2004
Vitamin D status and its relationship with bone mineral density in healthy Asian Indians.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.
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Who cites it
91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 275 citations in OpenAlex.
- High prevalence of vitamin D deficiency among the South Asian adults: a systematic review and meta-analysis.BMC public health · 2021Pooled it
- Primary hyperparathyroidism in developing world: a systematic review on the changing clinical profile of the disease.Archives of endocrinology and metabolism · 2020Pooled it
- Pooled it
- Vitamin D levels and deficiency with different occupations: a systematic review.BMC public health · 2017Pooled it
- Decreased bone mineral density in women with Sheehan's syndrome and improvement following oestrogen replacement and nutritional supplementation.Journal of bone and mineral metabolism · 2019Trial
- High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover.PloS one · 2012Trial
- Study protocol--metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: a randomised, placebo-controlled, double-blind vitamin D intervention.BMC public health · 2008Trial
- Bone mineral density in childhood acute lymphoblastic leukaemia survivors and factors affecting it.Medical journal, Armed Forces India · 2025Article
- Prevalence of Osteonecrosis in Survivors of Childhood Acute Lymphoblastic Leukaemia of Indian Ethnicity Treated with BFM Protocol.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- The Extensive Study of Magnesium Deficiency, 25-(OH) Vitamin D3, Inflammatory Markers, and Parathyroid Hormone in Relation to Bone Mineral Density in Iraqi Osteoporosis Patients: A Cross-Sectional Study.Health science reports · 2025Article
- Genu Valgum and Lamellar Ichthyosis: Insights into a Rare Presentation.Journal of orthopaedic case reports · 2025Article
- Ultrasonographic examination of the maturational effect of maternal vitamin D use on fetal clavicle bone development.BMC medical imaging · 2025Article
- From cultural dispositions to biological dimensions: a narrative review on the synergy between oral health and vitamin D through the lens of Indian habitus.Frontiers in oral health · 2025Review
- Vitamin D, body mass composition and metabolic risk factors in healthy young Indians.Medical journal, Armed Forces India · 2021Article
- Serum Levels of Vitamin D in Children with or without Isolated Distal Radius Fractures: A Prospective Clinical Study.Revista brasileira de ortopedia · 2021Article
- Effect of supplementation of vitamin D and calcium on patients suffering from chronic non-specific musculoskeletal pain: A pre-post study.Journal of family medicine and primary care · 2021Article
- Vitamin D deficiency in healthcare professionals across the network of an eye care organization in India.Indian journal of ophthalmology · 2021Article
- Evaluation of nutritional status of foreign students at King Saud University, Kingdom of Saudi Arabia.Public health nutrition · 2021Article
- Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study.International immunopharmacology · 2020Observational
- Hepatic osteodystrophy and fracture risk prediction using FRAX tool in Indian patients with cirrhosis.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthesis of vitamin D takes place in the skin under the effect of sunlight. The Indian subcontinent is situated between 8.4 degrees N and 37.6 degrees N latitudes and has adequate sunshine throughout the year. Thus, it has been presumed that Indians are vitamin D sufficient. We measured serum 25-hydroxy vitamin D [25(OH)D] ( n=92) and 1,25-dihydroxy vitamin D [1, 25(OH)(2)D] ( n=65) levels in healthy hospital staff, using (125)I radioimmunoassay. Serum intact parathyroid hormone (PTH) concentration was estimated by immunoradiometric assay. Bone mineral density was estimated using a dual energy X-ray absorptiometer (Hologic QDR 4500A). Using a serum 25(OH)D level of 15 ng/ml as a cutoff, 66.3% (61/92) of the subjects were found to be vitamin D deficient. Of these, 20.6% (19/92) subjects had severe vitamin D deficiency (<5 ng/ml), 27.2% (25/92) had moderate vitamin D deficiency (5-9.9 ng/ml), while 18.5% (17/92) had mild vitamin D deficiency (10-14.9 ng/ml). When a serum 25(OH)D level of 20 ng/ml was used as a cutoff, 78.3% subjects were diagnosed to be vitamin D deficient/insufficient. The serum 1,25(OH)(2)D level was within the normal range (40.6+/-20.1 pg/ml; mean +/- SD). Mean (+/-SD) serum intact PTH, estimated in a limited number of subjects (n=15), was 72.3 (+/-21.0) pg/ml (range 36-100 pg/ml). There was a significant correlation between daily sun exposure and 25(OH)D levels (r=0.731, P<0.001). The serum 25(OH)D level correlated with BMD at the femoral neck and Ward's triangle (r=0.50, P=0.020 and r=0.46, P=0.037, respectively). Our findings show that vitamin D deficiency is common in urban north Indian hospital staff. The possible reasons include inadequate sunlight exposure and skin pigmentation in Indians. The serum 1,25(OH)(2)D level is not a good indicator of vitamin D deficiency. A low serum 25(OH)D level is possibly one of the reasons for lower bone mineral density among Indians.
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