ArticlePsychopharmacology2004
Nicotine enhances responding with conditioned reinforcement.
Article in Psychopharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 139 citations in OpenAlex.
- The acute effects of nicotine on corticostriatal responses to distinct phases of reward processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Prolonged exposure to denicotinized cigarettes with or without transdermal nicotine.Drug and alcohol dependence · 2009Trial
- A double-blind placebo controlled experimental study of nicotine: I--effects on incentive motivation.Psychopharmacology · 2006Trial
- Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration.Psychopharmacology · 2026Review
- Nicotine enhances the ability of cues to control behavior and evoke dopamine release in the dorsolateral striatum.The Journal of pharmacology and experimental therapeutics · 2025Article
- Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement.Psychopharmacology · 2024Article
- Stimulus functions of nicotine.Advances in pharmacology (San Diego, Calif.) · 2022Article
- β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue.Frontiers in behavioral neuroscience · 2022Article
- Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.Psychopharmacology · 2021Article
- The pharmacological stressor yohimbine, but not U50,488, increases responding for conditioned reinforcers paired with ethanol or sucrose.Psychopharmacology · 2020Article
- Nicotinic Acetylcholine Receptor Signaling in the Hypothalamus: Mechanisms Related to Nicotine's Effects on Food Intake.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Review
- Nicotine Self-Administration With Tobacco Flavor Additives in Male Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Ethanol→Nicotine & Nicotine→Ethanol drug-sequence discriminations: Conditional stimulus control with two interoceptive drug elements in rats.Alcohol (Fayetteville, N.Y.) · 2019Article
- Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats.Pharmacology, biochemistry, and behavior · 2019Article
- Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice.Behavioural brain research · 2019Article
- Reinforcement enhancement by nicotine in adult rats: behavioral selectivity and relation to mode of delivery and blood nicotine levels.Psychopharmacology · 2018Article
- Strong seduction: impulsivity and the impact of contextual cues on instrumental behavior in alcohol dependence.Translational psychiatry · 2017Article
- Predictive but not emotional value of Pavlovian stimuli leads to pavlovian-to-instrumental transfer.Behavioural brain research · 2017Article
- Nicotine Acutely Enhances Reinforcement from Non-Drug Rewards in Humans.Frontiers in psychiatry · 2017Review
- Chronic Nicotine Exposure Initiated in Adolescence and Unpaired to Behavioral Context Fails to Enhance Sweetened Ethanol Seeking.Frontiers in behavioral neuroscience · 2017Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe mesolimbic dopamine system has been implicated in the primary reinforcing properties of drugs of abuse as well as in enhanced responding with conditioned reinforcement produced by psychomotor stimulant drugs. Despite clinical observations that nicotine self-administration (i.e. smoking) depends strongly upon conditioned reinforcement (i.e. cues support smoking behavior), little is known about whether nicotine directly affects motivational processes.
objectiveIn these experiments, we investigated whether acute nicotine would influence responding with conditioned reinforcement and the degree to which pretreatment with the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine would modify any nicotine-induced behavioral effects.
methodsAfter subjects had been trained to associate an initially neutral stimulus with water reward, they received acute nicotine (43,25-350 micro g/kg SC; -5 min) or saline injections and were tested on the acquisition of a new response for conditioned reinforcement paradigm. In separate experiments, the effect of pretreatment with the nicotinic acetylcholine receptor antagonist mecamylamine (300 or 1000 micro g/kg SC; -20 min) alone, or in combination with nicotine (350 micro g/kg SC; -5 min), on conditioned reinforcement was also examined.
resultsAcute nicotine injection produced a selective enhancement of responding with conditioned reinforcement (i.e. on the CR lever), without producing non-selective increases in overall responding. The effect of nicotine (350 micro g/kg SC; -5 min) was selectively blocked by mecamylamine (300 micro g/kg).
conclusionsThese findings demonstrate that acute exposure to nicotine augments the control over behavior by a conditioned reinforcer, suggesting that nicotine may enhance motivational processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.