ArticleOncogene2003
Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Aberrantly Expressed Genes and miRNAs in Slow Transit Constipation Based on RNA-Seq Analysis.BioMed research international · 2018Article
- PD-1 blockade restores impaired function of ex vivo expanded CD8OncoTargets and therapy · 2017Article
- Structure and function insights into the NuRD chromatin remodeling complex.Cellular and molecular life sciences : CMLS · 2015Review
- Familial colorectal cancer type X: genetic profiles and phenotypic features.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Review
- Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x.PloS one · 2013Article
- p12(CDK2-AP1) inhibits breast cancer cell proliferation and in vivo tumor growth.Journal of cancer research and clinical oncology · 2012Article
- Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region.The Journal of biological chemistry · 2012Article
- Double edge: CDK2AP1 in cell-cycle regulation and epigenetic regulation.Journal of dental research · 2012Review
- The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.PloS one · 2012Article
- MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.Molecular and cellular biology · 2006Article
- Gene expression signatures for colorectal cancer microsatellite status and HNPCC.British journal of cancer · 2005Article
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- Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity.Molecular cancer · 2004Article
- Microarray applications in cancer research.Cancer research and treatment · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The precise genetic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable colorectal cancer (CRC) has yet to be elucidated. We employed cDNA microarray to identify patterns of gene expression among CRC cell lines and to compare directly lines with and without microsatellite instability. This study was undertaken to test the hypothesis that microsatellite-unstable CRC cell lines demonstrate specific patterns of gene expression that differ significantly from those observed among microsatellite-stable CRC. Multiple differential expression patterns were identified. Genes demonstrating differential expression included deleted-in-oral-cancer-1 (DOC-1), a highly conserved growth suppressor. DOC-1 expression correlated with microsatellite status, with significantly decreased expression in microsatellite-unstable cell lines and constitutive expression in microsatellite-stable cell lines. We also observed alterations in the biologic behavior of p12(DOC-1)-deficient cell lines, with increased S phase and decreased apoptosis compared to microsatellite-stable (DOC-1+) cell lines. Transfection of p12(DOC-1) into SW48, which lacks p12(DOC-1) expression, resulted in cell cycle and apoptosis profiles similar to other p12(DOC-1)+ cell lines. These results support the hypothesis that microsatellite-unstable CRC is characterized by novel patterns of gene expression different from those associated with microsatellite-stable CRC, and demonstrate that p12(DOC-1) has tumor suppressor potential in colon epithelial cells.
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