ArticleProceedings of the National Academy of Sciences of the United States of America2003
Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms.Nature communications · 2024Article
- Clinical Validation ofBreast care (Basel, Switzerland) · 2018Article
- β-Catenin signaling is essential for mammalian larynx recanalization and the establishment of vocal fold progenitor cells.Development (Cambridge, England) · 2018Article
- Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis.Molecular cancer · 2013Article
- EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1.Cancer research · 2013Article
- Cyclins and cell cycle control in cancer and disease.Genes & cancer · 2012Article
- Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin.Biochimica et biophysica acta · 2012Article
- Fas-associated factor 1 is a scaffold protein that promotes β-transducin repeat-containing protein (β-TrCP)-mediated β-catenin ubiquitination and degradation.The Journal of biological chemistry · 2012Article
- Cadherin cell adhesion system in canine mammary cancer: a review.Veterinary medicine international · 2012Article
- Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis.Cancer cell · 2010Article
- Key signaling nodes in mammary gland development and cancer: β-catenin.Breast cancer research : BCR · 2010Review
- MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer.Expert review of molecular diagnostics · 2009Review
- Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo.The American journal of pathology · 2009Article
- Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis.Cancer research · 2009Article
- Article
- Nuclear insulin receptor substrate-1 activates promoters of cell cycle progression genes.Oncogene · 2008Article
- Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways.Annals of the New York Academy of Sciences · 2007Article
- Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study.BMC cancer · 2006Article
- Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing.The American journal of pathology · 2005Article
- Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.Molecular and cellular biology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A considerable body of circumstantial data suggests that cyclin D1 is an attractive candidate to mediate the effects of beta-catenin in mammary tissue. To test the functional significance of these correlative findings, we investigated the genetic interaction between transcriptionally active beta-catenin (DeltaN89beta-catenin) and its target gene cyclin D1 in the mouse mammary gland during pubertal development, pregnancy, and tumorigenesis. Our data demonstrate that cyclin D1 is dispensable for the DeltaN89beta-catenin-stimulated initiation of alveologenesis in virgin females, for the de novo induction of alveoli in males, and for the formation of tumors. Indeed, lack of cyclin D1 accentuates and enhances these hyperplastic and tumorigenic DeltaN89beta-catenin phenotypes. Although alveologenesis is initiated by DeltaN89beta-catenin in a cyclin D1-independent fashion, up-regulation of cyclin D1 occurs in DeltaN89beta-catenin mice and its expression remains essential for the completion of alveolar development during the later stages of pregnancy. Thus, alveologenesis is a two-step process, and cyclin D1 activity during late alveologenesis cannot be replaced by the activity of other beta-catenin target genes that successfully drive proliferation at earlier stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.