ArticleJournal of bioenergetics and biomembranes2003
In Saccharomyces cerevisiae, cations control the fate of the energy derived from oxidative metabolism through the opening and closing of the yeast mitochondrial unselective channel.
Article in Journal of bioenergetics and biomembranes, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Coupling/Uncoupling Reversibility in Isolated Mitochondria fromLife (Basel, Switzerland) · 2021Article
- Antimicrobial peptide CGA-N12 decreases the Candida tropicalis mitochondrial membrane potential via mitochondrial permeability transition pore.Bioscience reports · 2020Article
- Article
- Of yeast, mice and men: MAMs come in two flavors.Biology direct · 2017Review
- Calcium and reactive oxygen species in regulation of the mitochondrial permeability transition and of programmed cell death in yeast.Cell calcium · 2016Review
- The Saccharomyces cerevisiae mitochondrial unselective channel behaves as a physiological uncoupling system regulated by Ca2+, Mg2+, phosphate and ATP.Journal of bioenergetics and biomembranes · 2015Article
- Characterization of the respiration-induced yeast mitochondrial permeability transition pore.Yeast (Chichester, England) · 2013Article
- Mitochondria from Dipodascus (Endomyces) magnusii and Yarrowia lipolytica yeasts did not undergo a Ca²⁺-dependent permeability transition even under anaerobic conditions.Journal of bioenergetics and biomembranes · 2011Article
- Physiological uncoupling of mitochondrial oxidative phosphorylation. Studies in different yeast species.Journal of bioenergetics and biomembranes · 2011Article
- The mitochondrial permeability transition from yeast to mammals.FEBS letters · 2010Review
- Mitochondria from the salt-tolerant yeast Debaryomyces hansenii (halophilic organelles?).Journal of bioenergetics and biomembranes · 2010Article
- Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast.The Journal of cell biology · 2005Article
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Authors and funding
3 authors.
Funding
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Abstract
The yeast mitochondrial unspecific channel (YMUC) sensitivity to inorganic (Ca2+ or Mg2+) or organic (hexyl or octyl-guanidine) cations was measured. The rate of oxygen consumption in State 3 and State 4, the transmembrane potential (deltapsi), mitochondrial swelling, and the polyethylene-glycol mediated recontraction were used to follow opening of the YMUC. Addition of 0.4 mM PO4 did not close the YMUC, although it did enhance the sensitivity to Ca2+ (I50 decreased from 50 to 0.3 mM) and Mg2+ (I50 decreased from 5 to 0.83 mM Mg2+). The Ca2+ concentration needed to close the YMUC was higher than the concentrations usually observed in the cell. Nonetheless, Mg2+, Ca2+, and PO4 exhibited additive effects. These cations did not inhibit contraction of preswollen mitochondria, suggesting that the YMUC/cation interaction was labile. Octyl-guanidine (OG-I50 7.5 microM) was the only cation which inhibited mitochondrial recontraction, probably as a result of membrane binding stabilization through its hydrophobic tail. The PO4-dependent, Ca(2+)/Mg(2+)-mediated closure of the YMUC may be a means to control the proportion of oxidative energy producing ATP or being lost as heat.
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