ArticleThe Journal of clinical investigation1992
Rat glomerular mesangial cells synthesize basic fibroblast growth factor. Release, upregulated synthesis, and mitogenicity in mesangial proliferative glomerulonephritis.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 136 citations in OpenAlex.
- Establishment, Characterization, and Cryopreservation of Feather Follicle Fibroblast Lines From Hyacinth Macaw (Anodorhynchus hyacinthinus).Cell biology international · 2025Article
- L-glutamine supplementation reduced morphological damage in the renal glomerulus of rats with Walker-256 tumor.Acta cirurgica brasileira · 2023Article
- Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney.The American journal of pathology · 2015Article
- Signal transduction in podocytes--spotlight on receptor tyrosine kinases.Nature reviews. Nephrology · 2014Review
- High ambient glucose augments angiotensin II-induced proinflammatory gene mRNA expression in human mesangial cells: effects of valsartan and simvastatin.American journal of nephrology · 2009Article
- Peritoneal damage by peritoneal dialysis solutions.Clinical and experimental nephrology · 2008Review
- Sublytic complement C5b-9 complexes induce thrombospondin-1 production in rat glomerular mesangial cells via PI3-k/Akt: association with activation of latent transforming growth factor-beta1.Clinical and experimental immunology · 2006Article
- Fibroblast growth factor-2 increases the renal recruitment and attachment of HIV-infected mononuclear cells to renal tubular epithelial cells.Pediatric nephrology (Berlin, Germany) · 2005Article
- A 20-year history of childhood HIV-associated nephropathy.Pediatric nephrology (Berlin, Germany) · 2004Review
- Studies on mRNA expression of basic fibroblast growth factor in wound healing for wound age determination.International journal of legal medicine · 2003Article
- Mesangial cell gelatinase A synthesis is attenuated by oscillating hyperbaric pressure.The Biochemical journal · 2002Article
- Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis.The American journal of pathology · 2001Article
- Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy.Journal of endocrinological investigation · 1999Review
- Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo.The Journal of clinical investigation · 1998Article
- Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells.The Journal of clinical investigation · 1997Article
- Role of interleukin-1 in mesangial cell proliferation and matrix deposition in experimental mesangioproliferative nephritis.The American journal of pathology · 1997Article
- Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis.The American journal of pathology · 1996Article
- SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro.The American journal of pathology · 1996Article
- Basic fibroblast growth factor augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy.The Journal of clinical investigation · 1995Article
- Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis.The American journal of pathology · 1995Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Mesangial injury and cell proliferation are frequent findings in various glomerular diseases in man. Previous studies have demonstrated that basic fibroblast growth factor (bFGF) is a potent mesangial cell mitogen in vitro. To further elucidate the role of bFGF in rat mesangial cell (RMC) proliferation, we examined whether RMC synthesize bFGF in vitro and whether bFGF is involved in mesangial proliferation in vivo. Cultured RMC expressed bFGF protein (23, 21.5, and 18 kD forms) and bFGF mRNA, and released biologically active bFGF into the culture medium after antibody- and complement-mediated injury. Normal rat glomeruli in vivo contained no detectable bFGF mRNA, but bFGF protein (23 and 21.5 kD) could be demonstrated, which immunolocalized to the mesangium. Glomerular bFGF decreased markedly during the acute phase of glomerulonephritis induced by anti-Thy 1.1 antibody, compatible with mesangial bFGF release after complement-mediated mesangiolysis. During the subsequent mesangial proliferative phase, glomerular bFGF protein and mRNA increased above normal. Intrarenal infusion of heparin did not affect the bFGF immunostaining of glomeruli at this stage, indicating a predominantly intracellular localization of the bFGF. The capability of bFGF to mediate proliferation in the anti-Thy 1.1 model was further supported by experiments in which intravenous bFGF given 24 h after a subnephritogenic dose of anti-Thy 1.1 antibody led to a 4.9- to 5.1-fold increase in glomerular cell proliferation (with > 60% of the cells identified as mesangial cells by double immunolabeling). No such increase was observed in normal rats injected with bFGF. These data show that mesangial cells produce and release bFGF after injury and that bFGF is mitogenic for injured mesangial cells in vivo. Release of mesangial cell bFGF thus may be an important mechanism involved in the initiation of mesangial cell proliferation in vivo.
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