ArticleProceedings of the National Academy of Sciences of the United States of America1992
Coordinated regulation and inositol-mediated and fatty acid-mediated repression of fatty acid synthase genes in Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 78 citations in OpenAlex.
- Engineering yeast for tailored fatty acid profiles.Applied microbiology and biotechnology · 2025Review
- Fatty Acid Synthase: Structure, Function, and Regulation.Sub-cellular biochemistry · 2022Review
- Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline-auxotroph yeast.The EMBO journal · 2021Article
- Fatty Acid Synthase Beta Dehydratase in the Lipid Biosynthesis Pathway Is Required for Conidiogenesis, Pigmentation and Appressorium Formation inInternational journal of molecular sciences · 2020Article
- Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS).Scientific reports · 2020Article
- Impaired GCR1 transcription resulted in defective inositol levels, vacuolar structure and autophagy in Saccharomyces cerevisiae.Current genetics · 2019Article
- Transcriptional Comparison Investigating the Influence of the Addition of Unsaturated Fatty Acids on Aroma Compounds During Alcoholic Fermentation.Frontiers in microbiology · 2019Article
- Engineering fungal de novo fatty acid synthesis for short chain fatty acid production.Nature communications · 2017Article
- Recent advances in biosynthesis of fatty acids derived products in Saccharomyces cerevisiae via enhanced supply of precursor metabolites.Journal of industrial microbiology & biotechnology · 2015Review
- The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast.Chemistry and physics of lipids · 2014Review
- Phosphatidate phosphatase, a key regulator of lipid homeostasis.Biochimica et biophysica acta · 2013Review
- Review
- Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast.The Journal of biological chemistry · 2011Article
- Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans.The Journal of biological chemistry · 2009Article
- Dependence of arbuscular-mycorrhizal fungi on their plant host for palmitic acid synthesis.Applied and environmental microbiology · 2005Article
- Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray.Eukaryotic cell · 2004Article
- Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems.Microbiology and molecular biology reviews : MMBR · 2004Review
- Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae.Molecular and cellular biology · 2001Article
- Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Transcription of INO2 and INO4 is regulated by the state of protein N-myristoylation in Saccharomyces cerevisiae.Nucleic acids research · 1998Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In Saccharomyces cerevisiae, FAS1, FAS2, and FAS3 are the genes involved in saturated fatty acid biosynthesis. The enzymatic activities of both fatty acid synthase (FAS) and acetyl-CoA carboxylase are reduced 2- to 3-fold when yeast cells are grown in the presence of exogenous fatty acids. The mRNA levels of the FAS genes are correspondingly lower under repressive conditions. Expression of the FAS-lacZ reporter gene is also regulated by fatty acids. When a FAS2 multicopy plasmid is present in the cells, expression of both FAS1 and FAS3 increases. Thus, the FAS genes are coordinately regulated. Deletion analyses of the regulatory regions of FAS1 and FAS2 revealed common regulatory sequences. These include the GGCCAAAAAC and AGCCAAGCA sequences that have a common GCCAA core sequence and the UASINO (upstream activation sequence). Derepression of the FAS genes in the absence of exogenous inositol is not observed when UASINO is mutated, indicating that this cis element is a positive regulator of these genes. The GCCAA elements and UASINO act synergistically for optimal expression of the FAS genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.