ArticleGenetics1992
Comparative studies of Drosophila Antennapedia genes.
Article in Genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Use of a penetratin-linked peptide in Dictyostelium.Molecular biotechnology · 2006Article
- Conserved domains control heterochromatin localization and silencing properties of SU(VAR)3-7.Chromosoma · 2006Article
- Efficient use of a 'dead-end' GA 5' splice site in the human fibroblast growth factor receptor genes.The EMBO journal · 2003Article
- Activation of a cryptic 5' splice site by U1 snRNA.RNA (New York, N.Y.) · 2001Article
- Molecular organization of the Drosophila melanogaster Adh chromosomal region in D. repleta and D. buzzatii, two distantly related species of the Drosophila subgenus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- Article
- Genomic organization and evolution of alternative exons in a Drosophila calcium channel gene.Genetics · 1997Article
- Chromosomal homology and molecular organization of Muller's elements D and E in the Drosophila repleta species group.Genetics · 1997Article
- A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs.Nucleic acids research · 1997Article
- Splits in fruitfly Hox gene complexes.Nature · 1996Article
- Germline transformation of Drosophila virilis mediated by the transposable element hobo.Genetics · 1996Article
- Structure and regulation of the fushi tarazu gene from Drosophila hydei.Roux's archives of developmental biology : the official organ of the EDBO · 1995Article
- Conserved alternative splicing patterns and splicing signals in the Drosophila sodium channel gene para.Genetics · 1995Article
- Molecular characterization of the zerknüllt region of the Antennapedia complex of D. subobscura.Chromosoma · 1995Article
- Facilitated isolation of rare recombinants by ligase chain reaction: selection for intragenic crossover events in the Drosophila optomotor-blind gene.Molecular & general genetics : MGG · 1994Article
- Drive-selection equilibrium: homopolymer evolution in the Drosophila gene mastermind.Journal of molecular evolution · 1994Article
- Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila.Genetics · 1994Article
- Article
- The salivary gland chromosomes of Drosophila virilis: a cytological map, pattern of transcription and aspects of chromosome evolution.Chromosoma · 1993Article
- Gene regulation: translational initiation by internal ribosome binding.Current opinion in genetics & development · 1993Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The Antennapedia (Antp) homeotic gene of Drosophila melanogaster controls cell fates and pattern formation in the epidermis, nervous system and mesoderm of thoracic segments. Its expression is controlled at the levels of transcription, alternative RNA splicing, polyadenylation and translation. Two nested Antp transcription units extend over 103 kb and produce sixteen different transcripts. We have compared the Antp genes of Drosophila virilis, Drosophila subobscura and D. melanogaster to determine which structural features are conserved and therefore may be important to the gene's function. The overall gene structures are similar. There are many conserved sequence blocks throughout the large introns, at least 15 kb upstream of the first promoter, and at least 3 kb downstream of the last polyadenylation site. Intron and exon sequence conservation around alternative splice sites indicates that alternative protein coding forms may also be conserved. Protein coding potential is perfectly conserved around the C-terminal homeodomain, well conserved in the N-terminal region, and more variable in the middle. The large size of the Antp gene may reflect a large number of control elements necessary for appropriate Antp protein expression. The conservation of transcript complexity suggests functional requirements for the different protein forms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.