ArticleImmunology1992
Functional characterization of protective CD4+ T-cell clones reactive to the murine malaria parasite Plasmodium chabaudi.
Article in Immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 59 citations in OpenAlex.
- T cell transgressions: Tales of T cell form and function in diverse disease states.International reviews of immunology · 2022Review
- T cell responses: naive to memory and everything in between.Advances in physiology education · 2013Article
- Age-related differences in naturally acquired T cell memory to Plasmodium falciparum merozoite surface protein 1.PloS one · 2011Article
- Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice.Journal of parasitology research · 2011Article
- Tomatine adjuvantation of protective immunity to a major pre-erythrocytic vaccine candidate of malaria is mediated via CD8+ T cell release of IFN-gamma.Journal of biomedicine & biotechnology · 2010Article
- Macrophages expressing heat-shock protein 65 play an essential role in protection of mice infected with Plasmodium yoelii.Immunology · 1999Article
- Modulation of experimental blood stage malaria through blockade of the B7/CD28 T-cell costimulatory pathway.Immunology · 1999Article
- TAK-603 selectively suppresses Th1-type cytokine production and inhibits the progression of adjuvant arthritis.Immunology · 1997Article
- Reconstitution of B-cell-depleted mice with B cells restores Th2-type immune responses during Plasmodium chabaudi chabaudi infection.Infection and immunity · 1996Article
- Cellular mechanisms in the immune response to malaria in Plasmodium vinckei-infected mice.Infection and immunity · 1995Article
- Attenuated immunogenic parasites are essential in the transfer of immunity to virulent Plasmodium berghei.Immunology · 1995Article
- B cells are required for the switch from Th1- to Th2-regulated immune responses to Plasmodium chabaudi chabaudi infection.Infection and immunity · 1994Article
- Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria.Clinical and experimental immunology · 1994Article
- Expression of the IL-1 receptor discriminates Th2 from Th1 cloned CD4+ T cells specific for Plasmodium chabaudi.Immunology · 1994Article
- Predominance of infected reticulocytes in the peripheral blood of CD4+ T-cell-depleted mice chronically infected with Plasmodium chabaudi chabaudi.Parasitology research · 1994Article
- Differential induction of helper T cell subsets during blood-stage Plasmodium chabaudi AS infection in resistant and susceptible mice.Clinical and experimental immunology · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Protective immunity to asexual malaria parasites appears to be mediated predominantly by the CD4+ subset of T lymphocytes. To examine the role of this T-cell population in the immune response to the murine malaria parasite Plasmodium chabaudi, CD4+ clones derived from infected mice were raised and propagated in vitro. Analysis of the reactivity of clones responsive to parasite antigen demonstrated that the CD4+ cell response is heterogeneous and is consistent with the idea of two functionally distinct CD4+ subsets. Those populations derived early during primary infection secreted interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) upon antigenic stimulation in vitro, i.e. they had a cytokine repertoire typical of the delayed-type inflammatory T-helper 1 (Th1) CD4+ subset. In contrast, cells taken after clearance of a secondary infection produced IL-4 and acted as effective helper cells for anti-malarial antibody (Ab) synthesis in vitro, and thereby had the characteristics of Th2 cells. The appearance in vivo of Th1 and then Th2 clones specific for P. chabaudi-parasitized erythrocytes (pRBC) supports the proposal from limiting culture analyses that for this malaria parasite resolution of primary parasitaemia is predominantly through the action of cytokines rather than Ab, and that final clearance requires helper cells and specific immunoglobulin.
Indexed as
Identifiers
1356918PMC1421606W2260445928What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.