ArticleThe EMBO journal1992
Differential DNA sequence recognition is a determinant of specificity in homeotic gene action.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 146 citations in OpenAlex.
- Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes.Scientific reports · 2025Article
- Structural basis for the complex DNA binding behavior of the plant stem cell regulator WUSCHEL.Nature communications · 2020Article
- The expression profile and promoter analysis of ultraspiracle gene in the silkworm Bombyx mori.Molecular biology reports · 2014Article
- Expression analysis and RNA interference of BmCarE-10 gene from Bombyx mori.Molecular biology reports · 2014Article
- Role of Homeodomain leucine zipper (HD-Zip) IV transcription factors in plant development and plant protection from deleterious environmental factors.International journal of molecular sciences · 2013Review
- Analyzing the promoters of two CYP9A genes in the silkworm Bombyx mori by dual-luciferase reporter assay.Molecular biology reports · 2013Article
- Article
- The cis-regulatory code of Hox function in Drosophila.The EMBO journal · 2012Article
- Hox transcription factors influence motoneuron identity through the integrated actions of both homeodomain and non-homeodomain regions.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- The ABORTED MICROSPORES regulatory network is required for postmeiotic male reproductive development in Arabidopsis thaliana.The Plant cell · 2010Article
- Article
- Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences.Cell · 2008Article
- Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish.Developmental neurobiology · 2008Article
- Uterine receptivity and implantation: the regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium.Reproductive biology and endocrinology : RB&E · 2004Review
- Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1.Nucleic acids research · 2004Article
- Sequence-specific DNA binding by the vnd/NK-2 homeodomain of Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Target selectivity of bicoid is dependent on nonconsensus site recognition and protein-protein interaction.Molecular and cellular biology · 2000Article
- The yeast a1 and alpha2 homeodomain proteins do not contribute equally to heterodimeric DNA binding.Molecular and cellular biology · 1999Article
- A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function.Genetics · 1998Article
- Point mutations within and outside the homeodomain identify sequences required for proboscipedia homeotic function in Drosophila.Genetics · 1997Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The homeotic genes of Drosophila encode transcriptional regulatory proteins that specify distinct segment identities. Previous studies have implicated the homeodomain as a major determinant of biological specificity within these proteins, but have not established the physical basis of this specificity. We show here that the homeodomains encoded by the Ultrabithorax and Deformed homeotic genes bind optimally to distinct DNA sequences and have mapped the determinants responsible for differential recognition. We further show that relative transactivation by these two proteins in a simple in vivo system can differ by nearly two orders of magnitude. Such differences in DNA sequence recognition and target activation provide a biochemical basis for at least part of the biological specificity of homeotic gene action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.