ArticleThe EMBO journal1992
An autoregulatory element of the murine Hox-4.2 gene.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 106 citations in OpenAlex.
- An activity-specificity trade-off encoded in human transcription factors.Nature cell biology · 2024Article
- The Hox protein conundrum: The "specifics" of DNA binding for Hox proteins and their partners.Developmental biology · 2021Review
- Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection.Infection and immunity · 2018Article
- Article
- YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.PloS one · 2014Article
- Epigenetic regulations in hematopoietic Hox code.Oncogene · 2011Review
- An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4.Nucleic acids research · 2008Article
- Hox genes and their candidate downstream targets in the developing central nervous system.Cellular and molecular neurobiology · 2005Review
- Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments.Molecular and cellular biology · 2004Article
- The HOX homeodomain proteins block CBP histone acetyltransferase activity.Molecular and cellular biology · 2001Article
- Article
- Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.Molecular and cellular biology · 2000Article
- PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins.Molecular and cellular biology · 1999Article
- Article
- Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context.Molecular and cellular biology · 1998Article
- Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex.The EMBO journal · 1997Article
- Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4.Journal of virology · 1997Article
- Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis.Journal of virology · 1996Article
- Importance of the Ser-132 phosphorylation site in cell transformation and apoptosis induced by the adenovirus type 5 E1A protein.Journal of virology · 1996Article
- Functional interaction between a RARE and an AP-2 binding site in the regulation of the human HOX A4 gene promoter.Nucleic acids research · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox-4.2 promoter activity was assayed by transient expression assays in P19 embryonal carcinoma (EC) cells. Cotransfection of a luciferase reporter gene construct driven by Hox-4.2 upstream sequences with an expression vector for the Hox-4.2 gene product resulted in a 20-fold increase in luciferase activity. This activity was specific in that the Hox-1.6 gene product had no effect in the same assay. Mutational analysis defined a cis-acting element with enhancer function which conferred most of this increase. Activation was largely dependent on two TAAT/ATTA motifs within this 217 bp fragment and HOX-4.2 bound specifically to both of these motifs. The 217 bp element maps within a highly conserved region of the human Hox-4.2 gene (HOX4B) which has been shown to display spatial enhancer activity in mice and flies. These findings suggest a conserved autoregulatory mechanism for the control of Hox-4.2 expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.