ArticleImmunogenetics1992
Polymorphic analysis of the three MHC-linked HSP70 genes.
Article in Immunogenetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.
- Heat shock protein 70 gene polymorphisms and cancer risk: a meta-analysis.TheScientificWorldJournal · 2014Pooled it
- Alarmins as a Possible Target of Future Therapies for Atrial Fibrillation.International journal of molecular sciences · 2022Review
- Heat Shock Protein 70 Gene Single Nucleotide Polymorphism and Diabetic Foot Ulcer. Is There Any Relationship?Journal of clinical medicine · 2018Article
- Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population.The pharmacogenomics journal · 2017Article
- Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein-70 genes with diabetic nephropathy among South Indian population.Bioscience reports · 2017Article
- Heat shock protein 70 gene polymorphisms' influence on the electrophysiology of long QT syndrome.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2016Article
- Heat shock protein 70-2 and tumor necrosis factor-α gene polymorphisms in Chinese children with Henoch-Schönlein purpura.World journal of pediatrics : WJP · 2016Article
- Study of single nucleotide polymorphisms of tumour necrosis factors and HSP genes in nasopharyngeal carcinoma in North East India.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Analysis of heat shock protein 70 gene polymorphisms Mexican patients with idiopathic pulmonary fibrosis.BMC pulmonary medicine · 2015Article
- Heat-shock protein 70-2 BB genotype is associated with reduced risks of the steroid-dependent and refractory phenotypes of ulcerative colitis.Biomedical reports · 2014Article
- PharmGKB summary: abacavir pathway.Pharmacogenetics and genomics · 2014Article
- Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population.Cell stress & chaperones · 2014Article
- Genetic polymorphisms of HSP70 in age-related cataract.Cell stress & chaperones · 2013Article
- HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study.Molecular biology reports · 2012Article
- Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus.Annals of the rheumatic diseases · 2010Article
- Anti-inflammatory heat shock protein 70 genes are positively associated with human survival.Current pharmaceutical design · 2010Article
- Polymorphic analysis of MHClinked Heat Shock Protein 70 genes: Their susceptibility and prognostic implication in Kangri cancer cases of Kashmiri population.Indian journal of human genetics · 2009Article
- Article
- Protective role of genetic polymorphism of heat shock protein 70-2 for gastric cancer risk.Digestive diseases and sciences · 2009Article
- Association of HSP70-hom genetic variant with prostate cancer risk.Molecular biology reports · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three genes encoding members of the M(r) 70,000 heat shock protein family (HSP70) are known to lie in the class III region of the human major histocompatibility complex. In order to determine whether these genes or their protein products exhibit any polymorphism the three genes have been specifically amplified from genomic DNA and sequenced. The HSP70-1 and HSP70-2 genes encode the major heat-inducible HSP70. A comparison of the nucleotide sequences of these genes from B8, SC01, DR3, B18, F1C30, DR3, and B7, SC30, DR2 haplotypes has revealed only very limited sequence variation which is not associated with any amino acid polymorphism. The HSP70-Hom gene encodes a protein that is highly related to HSP70-1, but which is not heat-inducible. Nucleotide sequence analysis of this gene from different haplotypes has revealed a Met----Thr amino acid substitution at residue 493 in a number of the haplotypes tested. This variable amino acid lies in the proposed peptide-binding site of the HSP70-Hom protein.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.