Trial reportEuropean journal of clinical pharmacology1992
Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving.
Trial report in European journal of clinical pharmacology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 176 citations in OpenAlex.
- Histamine H1 receptor antagonist cetirizine impairs working memory processing speed, but not episodic memory.British journal of pharmacology · 2010Trial
- Rupatadine does not potentiate the CNS depressant effects of lorazepam: randomized, double-blind, crossover, repeated dose, placebo-controlled study.British journal of clinical pharmacology · 2010Trial
- Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance.British journal of clinical pharmacology · 2006Trial
- Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements.European journal of clinical pharmacology · 2004Trial
- Lack of interaction between two antihistamines, mizolastine and cetirizine, and ethanol in psychomotor and driving performance in healthy subjects.European journal of clinical pharmacology · 1995Trial
- Lack of interaction between a new antihistamine, mizolastine, and lorazepam on psychomotor performance and memory in healthy volunteers.British journal of clinical pharmacology · 1995Trial
- Effects of mizolastine and clemastine on actual driving and psychomotor performance in healthy volunteers.European journal of clinical pharmacology · 1994Trial
- Chronic Spontaneous Urticaria and Psychiatric Symptoms: The Blood-Brain Barrier Hypothesis.Experimental dermatology · 2026Review
- Examining the Impact of Digital Human Gaze Expressions on Engagement Induction.Biomimetics (Basel, Switzerland) · 2023Article
- Recognition of Empathy from Synchronization between Brain Activity and Eye Movement.Sensors (Basel, Switzerland) · 2023Article
- Validating lane drifts as a predictive measure of drug or sleepiness induced driving impairment.Psychopharmacology · 2020Article
- Using Patient Profiles To Guide The Choice Of Antihistamines In The Primary Care Setting In Malaysia: Expert Consensus And Recommendations.Therapeutics and clinical risk management · 2019Review
- Infrared Camera-Based Non-contact Measurement of Brain Activity From Pupillary Rhythms.Frontiers in physiology · 2018Article
- Effect of Cellular Mobile Phone Use and Cetrizine on Hand-Eye Coordination and Visual Acuity.Journal of clinical and diagnostic research : JCDR · 2017Article
- A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., "weaving") while driving at a blood alcohol concentration of 0.5 g/L.Psychopharmacology · 2017Article
- Lapses of attention as outcome measure of the on-the-road driving test.Psychopharmacology · 2014Article
- Neurophysiological pharmacodynamic measures of groups and individuals extended from simple cognitive tasks to more "lifelike" activities.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2013Article
- Article
- Statistical test of VEP waveform equality.Documenta ophthalmologica. Advances in ophthalmology · 2010Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sixteen healthy male and female volunteers took part in a 6-way, double-blind cross-over trial to compare the effects of single doses of cetirizine 10 mg, loratadine 10 mg and placebo, with and without alcohol (0.72 g.kg-1, lean body mass). Performance was measured in two repetitions of a psychometric test battery, and a standard, over-the-road driving test. EEG was also measured during driving. Alcohol significantly affected almost every performance measure and altered the EEG energy spectrum during driving whilst the blood concentrations declined from 0.37 to 0.20 mg.ml-1. The effects of cetirizine of on driving performance resembled those of alcohol. It caused the subjects to operate with significantly greater variability in speed and lateral position ('weaving' motion). The effects of alcohol and cetirizine appeared to be additive. Certain cetirizine-placebo differences in subjective feelings and test battery performance were also significant. Loratadine had no significant effect on any performance parameter. It was concluded that cetirizine, but not loratadine, generally caused mild impairment of performance after a single 10 mg dose.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.