ArticleBiophysical journal1992
Time course of transmitter release calculated from simulations of a calcium diffusion model.
Article in Biophysical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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Who cites it
102 citing papers in PubMed, 257 citations in OpenAlex.
- The Mechanism of LTXInternational journal of molecular sciences · 2025Article
- Physiology of intracellular calcium buffering.Physiological reviews · 2023Review
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- Article
- Dynamics of Neuromuscular Transmission Reproduced by Calcium-Dependent and Reversible Serial Transitions in the Vesicle Fusion Complex.Frontiers in synaptic neuroscience · 2021Article
- Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:CaeLife · 2020Article
- Synaptotagmin CaFrontiers in molecular neuroscience · 2018Review
- Review
- Modelling zinc changes at the hippocampal mossy fiber synaptic cleft.Journal of computational neuroscience · 2016Article
- Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.Journal of neurophysiology · 2016Article
- Phenotype-dependent Ca(2+) dynamics in single boutons of various anatomically identified GABAergic interneurons in the rat hippocampus.The European journal of neuroscience · 2016Article
- Modelling the vascular response to sympathetic postganglionic nerve activity.Journal of theoretical biology · 2015Article
- New insights into short-term synaptic facilitation at the frog neuromuscular junction.Journal of neurophysiology · 2015Article
- A use-dependent increase in release sites drives facilitation at calretinin-deficient cerebellar parallel-fiber synapses.Frontiers in cellular neuroscience · 2015Article
- Nanodomain coupling explains Ca²⁺ independence of transmitter release time course at a fast central synapse.eLife · 2014Article
- Synaptic properties of SOM- and CCK-expressing cells in dentate gyrus interneuron networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The functional significance of synaptotagmin diversity in neuroendocrine secretion.Frontiers in endocrinology · 2013Review
- Paired-pulse facilitation at recurrent Purkinje neuron synapses is independent of calbindin and parvalbumin during high-frequency activation.The Journal of physiology · 2013Article
- Insights on synaptic paired-pulse response using parametric and non-parametric models.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2013Article
- Short-term presynaptic plasticity.Cold Spring Harbor perspectives in biology · 2012Review
42 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A three-dimensional presynaptic calcium diffusion model developed to account for characteristics of transmitter release was modified to provide for binding of calcium to a receptor and subsequent triggering of exocytosis. When low affinity (20 microM) and rapid kinetics were assumed for the calcium receptor triggering exocytosis, and stimulus parameters were selected to match those of experiments, the simulations predicted a virtual invariance of the time course of transmitter release to paired stimulation, stimulation with pulses of different amplitude, and stimulation in different calcium solutions. The large temperature sensitivity of experimental release time course was explained by a temperature sensitivity of the model's final rate limiting exocytotic process. Inclusion of calcium tail currents and a saturable buffer with finite binding kinetics resulted in high peak calcium transients near release sites, exceeding 100 microM. Models with a single class of calcium binding site to the secretory trigger molecule failed to produce sufficient synaptic facilitation under this condition. When at least one calcium ion binds to a different site having higher affinity and slow kinetics, facilitation again reaches levels similar to those seen experimentally. It is possible that the neurosecretory trigger molecule reacts with calcium at more than one class of binding site.
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