ArticleAmerican journal of human genetics1992
Expected behavior of conditional linkage disequilibrium.
Article in American journal of human genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Genome-wide association study and genomic prediction of bolting trait in spinach (Frontiers in plant science · 2026Article
- Mathematical Properties of Linkage Disequilibrium Statistics Defined by Normalization of the Coefficient D = pAB - pApB.Human heredity · 2019Article
- Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population.The Korean journal of internal medicine · 2015Article
- Conditional asymmetric linkage disequilibrium (ALD): extending the biallelic r2 measure.Genetics · 2014Article
- How population growth affects linkage disequilibrium.Genetics · 2014Article
- Linkage disequilibrium measures for fine-scale mapping of disease loci are revisited.Frontiers in genetics · 2013Article
- The effect of genotyping errors on the robustness of composite linkage disequilibrium measures.Journal of genetics · 2011Article
- Information-theoretic identification of predictive SNPs and supervised visualization of genome-wide association studies.Nucleic acids research · 2006Article
- Random genetic drift and gamete frequency.Genetics · 2005Article
- Division of linkage disequilibrium between absolute linkage disequilibrium and linkage equilibrium.Journal of human genetics · 2005Article
- An E-M algorithm and testing strategy for multiple-locus haplotypes.American journal of human genetics · 1995Article
- Likelihood methods for locating disease genes in nonequilibrium populations.American journal of human genetics · 1995Article
- Maximum-likelihood estimation of gene location by linkage disequilibrium.American journal of human genetics · 1994Article
- Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mapping.American journal of human genetics · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ubiquitousness of RFLPs in the human genome has greatly helped the mapping of human disease genes, and it has been suggested that population measures of association between disease and marker loci could help with this mapping. For rare diseases, random samples are taken from within disease genotypes in order to obtain reasonable sample sizes, but this sampling strategy requires a modification of the usual measures of association. We present theoretical predictions for the mean and variance of such a modified measure, under the assumption that the disease gene is maintained at a constant low frequency in the population. The coefficient of variation of this modified measure is large enough that caution is needed in using the measure to locate disease genes, and, furthermore, the coefficient of variation cannot be made arbitrarily small by increasing sample size. The modified association measure is calculated for recently published data on cystic fibrosis.
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1353663PMC1682675W333938509What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.