ArticleJournal of clinical microbiology1992
Molecular typing of Staphylococcus aureus on the basis of coagulase gene polymorphisms.
Article in Journal of clinical microbiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed.
- Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults.Antimicrobial agents and chemotherapy · 2005Trial
- Virulence genes and antibiotic resistance profiling of staphylococcus species isolated from mastitic dairy cows in and around Bahir dar, Ethiopia.BMC microbiology · 2025Article
- Characterization of Staphylococcus aureus isolated from milk samples for their virulence, biofilm, and antimicrobial resistance.Scientific reports · 2024Article
- Coagulase-Negative Staphylococci in Neonatal Blood: How Concerning?Journal of laboratory physicians · 2023Article
- Antibodies to coagulase ofFrontiers in immunology · 2023Article
- Phylogenetic relationship, virulence factors, and biofilm formation ability of human, pet animals, and raw milkIranian journal of veterinary research · 2022Article
- Bovine subclinical mastitis-associated methicillin-resistantIranian journal of microbiology · 2021Article
- Review
- Characterization of methicillin-resistant3 Biotech · 2020Article
- Genetic Diversity and Virulence Factors ofInternational journal of microbiology · 2020Article
- Denture stomatitis associated with small-colony variants of Staphylococcus aureus: a case report.BMC oral health · 2019Article
- Coagulase gene polymorphisms ofAccess microbiology · 2019Article
- Antibiotic Susceptibility, Virulence Pattern, and Typing ofFrontiers in microbiology · 2019Article
- Detection of coagulase gene inVeterinary world · 2019Article
- Laboratory Methods in Molecular Epidemiology: Bacterial Infections.Microbiology spectrum · 2018Review
- Molecular typing ofVeterinary world · 2018Article
- Coagulase gene polymorphism, enterotoxigenecity, biofilm production, and antibiotic resistance in Staphylococcus aureus isolated from bovine raw milk in North West India.Annals of clinical microbiology and antimicrobials · 2017Article
- Detection of tetracycline resistance genes, aminoglycoside modifying enzymes, and coagulase gene typing of clinical isolates ofIranian journal of basic medical sciences · 2017Article
- Genetic Lineages of Methicillin-Resistant Staphylococcus aureus Acquired during Admission to an Intensive Care Unit of a General Hospital.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Staphylocoagulase, a major phenotypic determinant of Staphylococcus aureus, exists in multiple allelic forms, in part because of the existence of gene variants within the 3'-end coding region. This region contains a series of repeating 81-bp DNA sequences which differ both in the number of tandem repeats and the location of AluI restriction sites among different isolates. Utilizing this finding, we developed a novel typing method for S. aureus based on polymerase chain reaction amplification of the variable region of the coagulase gene followed by AluI restriction enzyme digestion and analysis of restriction fragment length polymorphism (RFLP). Among 30 S. aureus isolates studied initially, a total of 10 distinct RFLP patterns were observed. There was excellent correlation of the RFLP patterns with typing of these isolates by multilocus enzyme electrophoresis at 20 chromosomal loci. This coagulase RFLP method was used to analyze an additional 39 S. aureus isolates and successfully traced the source of an outbreak of methicillin-resistant S. aureus infections at a local hospital.
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