Evidence map›Paper›PMID 1352159›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society1992

Framework multipoint map of the long arm of human chromosome 4 and telomeric localization of the gene for FSHD.

B Weiffenbach, R G Bagley, K Falls, J Dubois, C Hyser, D Storvick, P Schultz, J R Mendell, E C Milner, S J Jacobsen

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In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

B WeiffenbachCollaborative Research, Inc., Waltham, Massachusetts 02154.
R G Bagley
K Falls
J Dubois
C Hyser
D Storvick
P Schultz
J R Mendell
E C Milner
S J Jacobsen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mapping the long arm of Chromosome (Chr) 4 has assumed medical relevance with the establishment of linkage of facioscapulohumeral muscular dystrophy (FSHD) to distal 4q markers. We have constructed a multipoint linkage map using DNA markers that map to the long arm of Chr 4. Segregation data were collected for 17 DNA markers on the multigenerational CEPH mapping families, and data for one marker were taken from the published CEPH database. Genotypic information for six of these markers was also collected from a set of 24 families that exhibited inheritance of FSHD. Multipoint analyses allowed us to construct a map of 12 loci, connecting two previously separate linkage groups. Significant sex-specific differences in recombination were found for some genetic intervals. Four loci from the distal region of this map showed linkage with FSHD. A map using these terminal markers gave the strongest support for FSHD in the most distal position over all other possible positions.

Indexed as

Chromosomes, Human, Pair 4Chromosome MappingFemaleGenetic LinkageHumansMaleMuscular DystrophiesPolymorphism, Restriction Fragment LengthSex CharacteristicsTelomere

Identifiers

PMID1352159

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.