ArticleBritish journal of cancer1992
Expression of c-erbB-2 protein in papillary thyroid carcinomas.
Article in British journal of cancer, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 76 citations in OpenAlex.
- Inverse prognostic impact of ErbB2 mRNA and protein expression level in tumors of soft tissue sarcoma patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Trial
- Review
- Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation.International journal of cancer · 2018Article
- Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer?Frontiers in endocrinology · 2017Review
- HER2 Analysis in Sporadic Thyroid Cancer of Follicular Cell Origin.International journal of molecular sciences · 2016Article
- Increased expression of EHF contributes to thyroid tumorigenesis through transcriptionally regulating HER2 and HER3.Oncotarget · 2016Article
- Lack of HER-2 gene amplification and association with pathological and clinical characteristics of differentiated thyroid cancer.Molecular and clinical oncology · 2014Article
- EGF and TGF-β1 Effects on Thyroid Function.Journal of thyroid research · 2011Article
- Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.Endocrine-related cancer · 2006Article
- S100A4 (Mts1) gene overexpression is associated with invasion and metastasis of papillary thyroid carcinoma.British journal of cancer · 2005Article
- Her2/neu overexpression in differentiated thyroid carcinomas predicts metastatic disease.Virchows Archiv : an international journal of pathology · 2003Article
- The IGF system in thyroid cancer: new concepts.Molecular pathology : MP · 2001 · on this mapReview
- Expression of wild-type p53 tumor suppressor gene and its possible involvement in the apoptosis of thyroid tumors.Surgery today · 1997Article
- Overexpression of the c-MET/HGF receptor in human thyroid carcinomas derived from the follicular epithelium.Journal of endocrinological investigation · 1995Article
- C-erbB-2 immunostaining: problems with interpretation.Journal of clinical pathology · 1994Article
- Prognostic impact of EGF-receptor in papillary thyroid carcinoma.British journal of cancer · 1993Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
c-erbB-2 protein expression was investigated immunohistochemically in frozen thyroid tissue specimens from 42 patients using a polyclonal sheep antibody. c-erbB-2 immunoreactivity was detected in 12 out of 17 papillary carcinomas, while no c-erbB-2 protein immunostaining was seen in cases of follicular adenoma (five cases), follicular carcinoma (five cases) or medullary carcinoma (one case), nor in cases of non-neoplastic tissue, including normal thyroid tissue from tumour-bearing glands. RNA was extracted from 51 thyroid tissue samples from 34 of the above patients, and c-erbB-2 mRNA was analysed by slot-blot hybridisation. c-erbB-2 mRNA was detectable in all samples, but papillary carcinomas and lymph node metastases showed significantly higher levels of c-erbB-2 mRNA compared to non-neoplastic tissue. The present demonstration of positive c-erbB-2 immunostaining in papillary thyroid carcinomas is contradictory to previous findings on formalin-fixed, paraffin-embedded material, and emphasises the importance of tissue quality for c-erbB-2 protein detection.
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