ArticleThe Journal of cell biology1992
Concentration-dependent regulation of neuronal gene expression by nerve growth factor.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 93 citations in OpenAlex.
- Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.Nature neuroscience · 2010Article
- Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties.Autonomic neuroscience : basic & clinical · 2009Review
- Regulation of low affinity neurotrophin receptor (p75(NTR)) by early growth response (Egr) transcriptional regulators.Molecular and cellular neurosciences · 2007Article
- Molecular and cellular biology of pheochromocytomas and extra-adrenal paragangliomas.Endocrine pathology · 2006Review
- Plasticity in rat uterine sympathetic nerves: the role of TrkA and p75 nerve growth factor receptors.Journal of anatomy · 2005Article
- Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR.The American journal of pathology · 2005Article
- Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- An element in the alpha1-tubulin promoter is necessary for retinal expression during optic nerve regeneration but not after eye injury in the adult zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase.The Journal of cell biology · 2003Article
- N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival.The Journal of cell biology · 1999Article
- Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Autocrine hepatocyte growth factor provides a local mechanism for promoting axonal growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death.The Journal of cell biology · 1998Article
- Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Rapid retrograde tyrosine phosphorylation of trkA and other proteins in rat sympathetic neurons in compartmented cultures.The Journal of cell biology · 1997Article
- Retrograde transport and steady-state distribution of 125I-nerve growth factor in rat sympathetic neurons in compartmented cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NGF is a neurotrophic protein that promotes the survival, growth, and differentiation of developing sympathetic neurons. To directly determine the effects of different concentrations of NGF on neuronal gene expression, we examined mRNAs encoding the p75 low-affinity NGF (LNGF) receptor, T alpha 1 alpha-tubulin (T alpha 1), and tyrosine hydroxylase (TH) in pure cultures of rat sympathetic neurons from postnatal day 1 superior cervical ganglia. Studies of the timecourse of gene expression during 2 wk in culture indicated that a 5-d incubation period would be optimal for the concentration-effect studies. Analysis of RNA isolated from neurons cultured in 2-200 ng/ml 2.5S NGF for 5 d revealed that, as the NGF concentration increased, neurons expressed correspondingly increased levels of all three mRNAs. Both LNGF receptor and TH mRNAs increased seven-fold, and T alpha 1 mRNA increased four-fold in neurons cultured in 200 versus 10 ng/ml NGF. In contrast, T26 alpha-tubulin mRNA, which is constitutively expressed, did not alter as a function of NGF concentration. When neurons were initially cultured in 10 ng/ml NGF for 5 d, and then 200 ng/ml NGF was added, LNGF receptor, T alpha 1, and TH mRNAs all increased within 48 h. The timecourse of induction differed: T alpha 1 mRNA was maximal by 5 h, whereas LNGF receptor and TH mRNAs first began to increase at 12 h after the NGF increase. These experiments show that NGF regulates expression of a subset of mRNAs important to neuronal growth and differentiation over a broad concentration range, suggesting that the effects of NGF may be mediated by more than just a single receptor operating at one fixed affinity. These results also suggest a mechanism for coupling neuronal synthesis of axonal proteins to increases in size of the innervated target territory during growth of the organism.
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