ArticleMolecular and cellular biology1992
Expression of the CD4 gene requires a Myb transcription factor.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 124 citations in OpenAlex.
- Revealing potential signaling pathways and hub genes related to monocytes in sepsis survivors and non-survivors based on single-cell RNA-seq and bulk RNA-seq data.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- MYB oncoproteins: emerging players and potential therapeutic targets in human cancer.Oncogenesis · 2021Review
- Myb proteins regulate expression of histone variant H2A.Z during thymocyte development.Immunology · 2008Article
- c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.The EMBO journal · 2007Article
- v-Myb represses the transcription of Ets-2.Oncogene · 2007Article
- The carbonic anhydrase I locus contains a c-Myb target promoter and modulates differentiation of murine erythroleukemia cells.Oncogene · 2006Article
- Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells.Molecular pathology : MP · 2002Article
- Identification and characterization of the Myb-inducible promoter of the chicken adenosine receptor 2B gene.Oncogene · 2002Article
- Article
- Transcriptional coordination of the genes encoding catalytic (CK2alpha) and regulatory (CK2beta) subunits of human protein kinase CK2.Molecular and cellular biochemistry · 2001Article
- The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes.The Journal of experimental medicine · 2001Article
- Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.Molecular and cellular biology · 2001Article
- c-Myb binds to a sequence in the proximal region of the RAG-2 promoter and is essential for promoter activity in T-lineage cells.Molecular and cellular biology · 2000Article
- Precise arrangement of factor-binding sites is required for murine CD4 promoter function.Nucleic acids research · 2000Article
- Independent repressor domains in ZEB regulate muscle and T-cell differentiation.Molecular and cellular biology · 1999Article
- Subclass-specific nuclear localization of a novel CD4 silencer binding factor.The Journal of experimental medicine · 1999Article
- Review
- c-Myb is essential for early T cell development.Genes & development · 1999Article
- The notch pathway intermediate HES-1 silences CD4 gene expression.Molecular and cellular biology · 1998Article
- CD4 promoter transactivation by human herpesvirus 6.Journal of virology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have analyzed the control of developmental expression of the CD4 gene, which encodes an important recognition molecule and differentiation antigen on T cells. We have determined that the CD4 promoter alone functions at high levels in the CD4+ CD8- mature T cell but not at the early CD4+ CD8+ stage of T-cell development. In addition, the CD4 promoter functions only in T lymphocytes; thus, the stage and tissue specificity of the CD4 gene is mediated in part by its promoter. We have determined that a Myb transcription factor binds to the CD4 promoter and is critical for full promoter function. Thus, Myb plays an important role in the expression of T-cell-specific developmentally regulated genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.