ArticleImmunogenetics1992
Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset.
Article in Immunogenetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- A comprehensive review of the genetics of juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2008Article
- Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus.American journal of human genetics · 2001Article
- Genetic background and environment contribute synergistically to the onset of autoimmune diseases.Journal of molecular medicine (Berlin, Germany) · 1995Review
- PCR-based genotyping and haplotype analysis of human TCRBV gene segment polymorphisms.Immunogenetics · 1995Article
- Immunoprinting: various genes are associated with increased risk to develop rheumatoid arthritis in different groups of adult patients.Journal of molecular medicine (Berlin, Germany) · 1995Article
- Immunopathogenesis of juvenile rheumatoid arthritis: role of T cells and MHC.Immunologic research · 1995Review
- Level of human TCRBV3S1 (V beta 3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence.The Journal of experimental medicine · 1994Article
- Analysis of overlapping T- and B-cell antigenic sites on rubella virus E1 envelope protein. Influence of HLA-DR4 polymorphism on T-cell clonal recognition.Human immunology · 1994Article
- Polymorphism detection and sequence analysis of human T-cell receptor V alpha-chain-encoding gene segments.Immunogenetics · 1994Article
- Analysis of a T-cell receptor V beta segment implicated in susceptibility to rheumatoid arthritis: V beta 2 germline polymorphism does not encode susceptibility.Annals of the rheumatic diseases · 1993Article
- Vb6 T-cell receptor elements in artiodactyls: conservation and germline polymorphisms.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Lack of association with T-cell receptor TCRBV6S1*2 allele in HLA-DQA1*0101-positive Norwegian juvenile chronic arthritis patients.Immunogenetics · 1993Article
- Human Tcrb-V6.10 is a pseudogene with Alu repetitive sequences in the promoter region.Immunogenetics · 1993Article
- Allelic polymorphism of human T-cell receptor V alpha gene segments.Immunogenetics · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
This report demonstrates a T-cell receptor (Tcr) restriction fragment length polymorphism, defined by a Tcrb-V6.1 gene probe and Bgl II restriction enzyme, to be absolutely correlated with allelic variation in the coding sequence of a Tcrb-V6.1 gene. A pair of non-conservative amino acid substitutions distinguish the Tcrb-V6.1 allelic variants. An association of this Tcrb-V6.1 gene allelic variant with one form of juvenile rheumatoid arthritis (JRA) was established in a cohort of 126 patients. The association was observed in patients possessing the HLA-DQA1*0101 gene. Among HLA-DQA*0101 individuals, 19 of 26 patients (73.1%) carried one particular Tcrb-V6.1 gene allele as opposed to 11 of 33 controls (33%; p less than 0.005). Haplotypes carrying this HLA gene have previously been shown to confer increased risk for progression of arthritis in JRA. This demonstration of a disease-associated Tcrb-V gene allelic variant has not, to our knowledge, been previously reported and supports the contribution of polymorphism in the Tcr variable region genomic repertoire to human autoimmune disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.