ArticleThe Journal of experimental medicine1992
Mapping of the nu gene using congenic nude strains and in situ hybridization.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Simple generation of hairless mice for in vivo imaging.Experimental animals · 2017Article
- Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting.Scientific reports · 2017Article
- CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rgScientific reports · 2017Article
- Current limitations of murine models in oncology for ascorbate research.Frontiers in oncology · 2014Review
- Hairless mutation: a driving force of humanization from a human-ape common ancestor by enforcing upright walking while holding a baby with both hands.Genes to cells : devoted to molecular & cellular mechanisms · 2012Article
- Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis.International journal of biological sciences · 2012Review
- DiGeorge syndrome: an historical review of clinical and cytogenetic features.Journal of medical genetics · 1993Review
- Regional localization of the nu mutation on mouse chromosome 11.Immunogenetics · 1993Article
- Genetic mapping of the athymic nude (RNU) locus in the rat to a region on chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chromosomal location of the nu gene, which is responsible for hairlessness and athymus, was determined using six DNA markers (interleukin 3 [Il-3], Myhs, Acrb, Evi-2, Mpo, and Hox-2) on mouse chromosome 11. We constructed the high-resolution physical mapping of the six DNA markers on chromosome 11 by in situ hybridization using fluorescence-labeled cosmid probes. The results indicate the order of centromere-(41cM)-Il-3-(3cM)-Myhs- (4cM)-Acrb-(6cM)-Evi-2-(3cM)-Mpo-(5cM)- Hox-2. We have used congenic nude strains and examined which of the six DNA markers were derived from the original nude mouse. We found the Evi-2 locus is linked to the nu gene in all the informative, independent congenic nude strains. From these data, we could estimate the location of the nu gene, not only genetically but also physically within a region that spans approximately 17 megabases (9 cM) between the Acrb and Mpo genes.
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