ArticleThe EMBO journal1992
The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 85 citations in OpenAlex.
- Hoxb genes determine the timing of cell ingression by regulating cell surface fluctuations during zebrafish gastrulation.Development (Cambridge, England) · 2025Article
- LncRNA-SULT1C2A regulates Foxo4 in congenital scoliosis by targeting rno-miR-466c-5p through PI3K-ATK signalling.Journal of cellular and molecular medicine · 2019Article
- Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection.Infection and immunity · 2018Article
- Article
- "Self-regulation," a new facet of Hox genes' function.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Identification and analysis of vnd/NK-2 homeodomain binding sites in genomic DNA.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context.Molecular and cellular biology · 1998Article
- HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas.The American journal of pathology · 1997Article
- Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex.The EMBO journal · 1997Article
- Sequence and expression of the murine Hoxd-3 homeobox gene.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Characterization of the murine Hoxc-5 gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
- Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2.Molecular and cellular biology · 1995Article
- The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes.Molecular and cellular biology · 1995Article
- Multiple positive and negative regulatory elements in the promoter of the mouse homeobox gene Hoxb-4.Molecular and cellular biology · 1994Article
- Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm.Molecular and cellular biology · 1994Article
- The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.The EMBO journal · 1994Article
- The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.The EMBO journal · 1994Article
- Inhibition of retinoic acid-induced activation of 3' human HOXB genes by antisense oligonucleotides affects sequential activation of genes located upstream in the four HOX clusters.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Functional analysis of mouse Hoxa-7 in Saccharomyces cerevisiae: sequences outside the homeodomain base contact zone influence binding and activation.Molecular and cellular biology · 1994Article
- Isolation and characterization of target sequences of the chicken CdxA homeobox gene.Nucleic acids research · 1993Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the structure, regulation and expression of HOX3D, a human homeobox gene located in the HOX3 cluster on chromosome 12. HOX3D is developmentally regulated during embryogenesis and is activated by retinoic acid (RA) in cultured embryonal carcinoma (EC) cells. Transfection of HOX3D upstream genomic sequences linked to a reporter gene allowed the functional definition of its promoter, containing a canonical TATA element. This promoter directs the expression of the reporter gene in EC cells after induction with RA, and binds RA-induced nuclear factor(s) through a conserved palindromic sequence located approximately 100 bp upstream of the transcription start site. The HOX3D promoter is transactivated in both human and murine cells when cotransfected with vectors expressing the protein product of the upstream gene HOX3C and the paralogs of further upstream genes in the HOX4 cluster (i.e. HOX4D, HOX4C and the murine Hox 4.3). The HOX3D protein, and those encoded by the downstream gene HOX3E and its paralog HOX4B are instead inactive. HOX4C and HOX4D proteins synthesized in bacteria bind to the same conserved sequence located around position -120, as well as to the TATA box and immediately upstream and downstream nucleotides. These data provide evidence that cross-regulatory interactions between mammalian homeogenes take place in cultured cells, thus raising the possibility that a regulatory network may exist in vivo. The sequences on the HOX3D promoter involved in cross-regulation are different from those binding nuclear factors induced by RA.
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