ReviewThe Yale journal of biology and medicine
Praomys (Mastomys) natalensis: a model for gastric carcinoid formation.
Review in The Yale journal of biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha.Molecular biology and evolution · 2019Article
- Gastric Neuroendocrine Tumors (Carcinoids).Current gastroenterology reports · 2019Review
- Review
- Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models.Disease models & mechanisms · 2018Review
- Review
- Care of Mastomys in the laboratory.Lab animal · 2016Article
- Ultrastructure of ECL cells in Mastomys after long-term treatment with H2 receptor antagonist loxtidine.Medical molecular morphology · 2012Article
- Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors.Journal of the National Cancer Institute · 2008Article
- Gastric cancer: animal studies on the risk of hypoacidity and hypergastrinemia.World journal of gastroenterology · 2008Review
- Observations on relationship between hypergastrinemia, multiple gastric carcinoids, and pancreatic mass.Digestive diseases and sciences · 1996Article
- Histamine metabolism of gastric carcinoids in Mastomys natalensis.The Yale journal of biology and medicineReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gastric carcinoid tumors of Praomys (Mastomys) natalensis have been reviewed with respect to histogenesis, development, biochemistry, and morphological properties. Multicentric gastric carcinoids frequently develop in the oxyntic mucosa of aging Mastomys. The development of these tumors can be significantly enhanced by drug-induced hypergastrinemia, e.g., histamine2-receptor blockade. Spontaneous and drug-induced gastric carcinoids are endocrine in nature, as evidenced by their argyrophilic staining properties and chromogranin A content. They are also rich in histidine decarboxylase activity and produce large amounts of histamine, although other hormones, such as peptide YY and enteroglucagon, have also been demonstrated in these tumors. Ultrastructurally, gastric carcinoids are composed of tumor cells with typical secretory granules resembling those of enterochromaffin-like (ECL) cells. A close examination of the gastric carcinoids in Mastomys reveals striking similarities with gastric carcinoids developing in humans suffering from chronic atrophic gastritis type A or from the Zollinger-Ellison syndrome in combination with multiple endocrine neoplasia type 1 (MEN-1). Both these conditions are associated with hypergastrinemia and a higher risk for developing multi-centric gastric carcinoids of ECL-cell origin. The Mastomys tumor model therefore appears to be a significant experimental model in which induction and formation of gastric carcinoid tumors can be studied.
Indexed as
Identifiers
1341076PMC2589773W2403609530What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.