ArticleThe Journal of cell biology1992
The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 126 citations in OpenAlex.
- ZW10: an emerging orchestrator of organelle dynamics during the cell division cycle.Journal of molecular cell biology · 2024Review
- The Role of Mitotic Kinases and the RZZ Complex in Kinetochore-Microtubule Attachments: Doing the Right Link.Frontiers in cell and developmental biology · 2022Review
- Dynamics of kinetochore structure and its regulations during mitotic progression.Cellular and molecular life sciences : CMLS · 2020Review
- Polo regulates Spindly to prevent premature stabilization of kinetochore-microtubule attachments.The EMBO journal · 2020Article
- Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes.Histochemistry and cell biology · 2019Article
- The checkpoint protein Zw10 connects CAL1-dependent CENP-A centromeric loading and mitosis duration in Drosophila cells.PLoS genetics · 2019Article
- Epistatic Analysis of the Contribution of Rabs and Kifs to CATCHR Family Dependent Golgi Organization.Frontiers in cell and developmental biology · 2019Article
- Phenotypic characterization of diamond (dind), a Drosophila gene required for multiple aspects of cell division.Chromosoma · 2018Article
- Article
- Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila.Journal of developmental biology · 2018Article
- Rs2459976 inOncotarget · 2018Article
- The Hybrid Incompatibility GenesGenetics · 2017Article
- dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.Chromosoma · 2017Article
- The spindle checkpoint and chromosome segregation in meiosis.The FEBS journal · 2015Review
- RZZ and Mad1 dynamics in Drosophila mitosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.Journal of cell science · 2015Article
- Simple method for fluorescence DNA in situ hybridization to squashed chromosomes.Journal of visualized experiments : JoVE · 2015Article
- How Rab proteins determine Golgi structure.International review of cell and molecular biology · 2015Review
- The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation.Cell cycle (Georgetown, Tex.) · 2015Article
- Function and regulation of dynein in mitotic chromosome segregation.Chromosoma · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mutations in the gene l(1)zw10 disrupt the accuracy of chromosome segregation in a variety of cell types during the course of Drosophila development. Cytological analysis of mutant larval brain neuroblasts shows very high levels of aneuploid cells. Many anaphase figures are aberrant, the most frequent abnormality being the presence of lagging chromosomes that remain in the vicinity of the metaphase plate when the other chromosomes have migrated toward the spindle poles. Finally, the centromeric connection between sister chromatids in mutant neuroblasts treated with colchicine often appears to be broken, in contrast with similarly treated control neuroblasts. The 85-kD protein encoded by the l(1)zw10 locus displays a dynamic pattern of localization in the course of the embryonic cell cycle. It is excluded from the nuclei during interphase, but migrates into the nuclear zone during prometaphase. At metaphase, the zw10 antigen is found in a novel filamentous structure that may be specifically associated with kinetochore microtubules. Upon anaphase onset, there is an extremely rapid redistribution of the zw10 protein to a location at or near the kinetochores of the separating chromosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.