ArticleThe Journal of physiology1992
Modulation of calcium current gating in frog skeletal muscle by conditioning depolarization.
Article in The Journal of physiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Ca2+/CaM-dependent inactivation of the skeletal muscle L-type Ca2+ channel (Cav1.1).Pflugers Archiv : European journal of physiology · 2008Article
- Functional roles of the gamma subunit of the skeletal muscle DHP-receptor.Journal of muscle research and cell motility · 2006Review
- Convergent regulation of skeletal muscle Ca2+ channels by dystrophin, the actin cytoskeleton, and cAMP-dependent protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Beta subunits of voltage-gated calcium channels.Journal of bioenergetics and biomembranes · 2003Review
- Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes.The Journal of physiology · 2000Article
- Kinetics of inactivation and restoration from inactivation of the L-type calcium current in human myotubes.The Journal of physiology · 1999Article
- Effect of nifedipine on depolarization-induced force responses in skinned skeletal muscle fibres of rat and toad.Journal of muscle research and cell motility · 1998Article
- L-type calcium current activation in cultured human myotubes.Journal of muscle research and cell motility · 1997Article
- Voltage-dependent modulation of T-type calcium channels by protein tyrosine phosphorylation.The EMBO journal · 1997Article
- Modulation of the cloned skeletal muscle L-type Ca2+ channel by anchored cAMP-dependent protein kinase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Activation of L-type calcium channel in twitch skeletal muscle fibres of the frog.The Journal of physiology · 1996Article
- Calcium current reactivation after flash photolysis of nifedipine in skeletal muscle fibres of the frog.The Journal of physiology · 1995Article
- Involvement of dihydropyridine receptors in terminating Ca2+ release in rat skeletal myotubes.The Journal of physiology · 1995Article
- Skeletal muscle DHP receptor mutations alter calcium currents in human hypokalaemic periodic paralysis myotubes.The Journal of physiology · 1995Article
- Simultaneous expression of cardiac and skeletal muscle isoforms of the L-type Ca2+ channel in a rat heart muscle cell line.The Journal of physiology · 1994Article
- Relationship of calcium transients to calcium currents and charge movements in myotubes expressing skeletal and cardiac dihydropyridine receptors.The Journal of general physiology · 1994Article
- A possible role of sarcoplasmic Ca2+ release in modulating the slow Ca2+ current of skeletal muscle.Pflugers Archiv : European journal of physiology · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Ca2+ inward currents were measured by voltage clamping cut skeletal muscle fibres of the frog (Rana esculenta) in a double-Vaseline-gap system. 2. In order to study the basis of the previously described fast gating mode induced in the Ca2+ inward current by a conditioning depolarization we quantitatively analysed the response to differing features of the conditioning prepulse. 3. The faster activation seen during the second of two depolarizations was confined to the component of the inward current which could be blocked by 5 to 10 microM nifedipine. 4. By applying depolarizing conditioning pulses of gradually increasing length the time course of the transition to the fast gating mode could be determined. 5. Both the transition to the fast gating mode (point 4) caused by a depolarization and the slow inward current activated during the same depolarization showed similar voltage-dependent kinetics. 6. The kinetic change of the test current appeared to be equal when the same fractional activation was achieved at the end of the conditioning pulse independent of its duration or amplitude. 7. Flash photolysis of nifedipine in the interval between conditioning and test pulse showed that the predepolarization causes a rate-enhancing effect even though the slow channels were blocked by nifedipine during the conditioning pulse. 8. We conclude that the transition of the calcium channel from its slow to its fast gating mode is determined by the slow voltage-dependent reaction which limits the rate of channel opening under control conditions. This reaction is apparently not prevented by the binding of nifedipine and the block of current flow through the channel.
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