ArticleMolecular biology of the cell1992
Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm.
Article in Molecular biology of the cell, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 71 citations in OpenAlex.
- Molecular analysis of a ras-like nuclear (Ran) gene from Penaeus monodon and its expression at the different ovarian stages of development.Molecular biology reports · 2012Article
- Article
- Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells.Molecular biology of the cell · 2003Article
- Plk1 promotes nuclear translocation of human Cdc25C during prophase.EMBO reports · 2002Article
- Cell cycle checkpoints and their inactivation in human cancer.Cell proliferation · 2000Review
- Nuclei and microtubule asters stimulate maturation/M phase promoting factor (MPF) activation in Xenopus eggs and egg cytoplasmic extracts.The Journal of cell biology · 2000Article
- Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import.The EMBO journal · 1999Article
- Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1.Genes & development · 1998Article
- 14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts.Molecular biology of the cell · 1998Article
- A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.The Journal of cell biology · 1997Article
- Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1.The EMBO journal · 1996Article
- COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus.The Journal of cell biology · 1995Article
- RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4.Molecular & general genetics : MGG · 1995Article
- Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.Molecular and cellular biology · 1995Article
- Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Effects of mutant Ran/TC4 proteins on cell cycle progression.Molecular and cellular biology · 1994Article
- Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.Molecular biology of the cell · 1993Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We cloned the hamster cdc25C cDNA by using the human cdc25C cDNA as a probe and prepared an antibody to Escherichia coli-produced hamster cdc25C protein that is specific to the human cdc25C protein. The microinjected antibody inhibited a chromosome condensation induced by tsBN2 mutation, indicating that the cdc25C protein is required for an activation of p34cdc2 kinase caused by loss of RCC1 function. The hamster cdc25C protein located in the cytoplasm, prominently in a periphery of the nuclei of cells arrested with hydroxyurea, and seemed to move into the nuclei by loss of RCC1 function. Also, we found a molecular shift of the cdc25C protein in cells showing premature chromosome condensation (PCC), in addition to normal mitotic cells. This molecular-shift appeared depending on an activation of p34cdc2 kinase.
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