ArticleImmunology1992
Expression of cytokines and their receptors by human thymocytes and thymic stromal cells.
Article in Immunology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 71 citations in OpenAlex.
- SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development.Frontiers in immunology · 2021Article
- Potential implications of interleukin-7 in chronic wound healing.Experimental and therapeutic medicine · 2016Article
- Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems.Biomolecules · 2015Review
- c-kit plays a critical role in induction of intravenous tolerance in experimental autoimmune encephalomyelitis.Immunologic research · 2015Article
- Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn1(-/-) mice.Cellular & molecular immunology · 2014Article
- Regulation of mu opioid receptor expression in developing T cells.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby.BMC genomics · 2011Article
- Cytokines, leptin, and stress-induced thymic atrophy.Journal of leukocyte biology · 2008Review
- Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection.Journal of neurovirology · 2005Article
- Characterizing the immune system after long-term undetectable viral load in HIV-1-infected children.Journal of clinical immunology · 2003Article
- Identification, structural characterization, and tissue distribution of Tsg-5: a new TNF-stimulated gene.Genes and immunity · 2003Article
- Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type 1-positive individuals.Journal of virology · 2001Article
- High-level replication of human immunodeficiency virus in thymocytes requires NF-kappaB activation through interaction with thymic epithelial cells.Journal of virology · 1999Article
- Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells.The Journal of experimental medicine · 1998Article
- Contact with thymic epithelial cells as a prerequisite for cytokine-enhanced human immunodeficiency virus type 1 replication in thymocytes.Journal of virology · 1998Article
- Interleukin-7 treatment promotes the differentiation pathway of T-cell-receptor-alpha beta cells selectively to the CD8+ cell lineage.Immunology · 1997Article
- Interleukin-7 is a potent co-stimulus of the adhesion pathway involving CD2 and CD28 molecules.Immunology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repertoire of cytokine and cytokine receptor mRNA expressed by unstimulated human thymocytes and thymic stromal cells was explored by a quantitative polymerase chain reaction (PCR) using sequence specific internal standards. Of the 18 cytokines tested we found a considerable overlap in the expression of cytokines by human thymocytes and by thymic stromal cells; both cell types express the mRNA for interleukin-1 beta(IL-1, IL-6, IL-7 and tumour necrosis factor-alpha (TNF-alpha). However, there are substantial differences in the levels of cytokine mRNA expressed in these two types of cells as revealed by the quantitative PCR assay. Stromal cells express considerably higher levels of IL-1 beta and IL-6 than thymocytes (14- and 27-fold respectively). In addition, a number of cytokines such as lymphotoxin and interferon-gamma (IFN-gamma), are expressed exclusively in thymocytes whereas others such as stem cell factor (SCF), IL-1 receptor antagonist-2 (IRAP-2) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are produced only in stromal cells. There is a complete overlap in the expression of a group of cytokine receptors tested in thymocytes and thymic stromal cells; these include IL-1R, IL-2R, IL-6R, IL-7R, TNFR and stem cell growth factor receptor (c-KIT). The expression of specific cytokines by thymic stromal cells and the parallel expression of their receptors on thymocytes under physiological conditions, support the hypothesis that these cytokines participate in paracrine interactions between these two cell populations during thymocyte differentiation.
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Identifiers
1335959PMC1421705W97519605What OpenQuestion holds
Registered trials
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