Evidence map›Paper›PMID 1335936›Full record

ReviewDiabetologia1992

Structural biology and diabetes mellitus: molecular pathogenesis and rational drug design.

T Blundell, R Hubbard, M A Weiss

Abstract readReview
PubMed Publisher
In one paragraph

Review in Diabetologia, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

T BlundellDepartment of Crystallography, Birkbeck College, University of London, UK.
R Hubbard
M A Weiss

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging concepts in the aetiology and pathogenesis of Type 1 (insulin-dependent) diabetes mellitus may offer new opportunities for treatment and cure. Here we describe recent advances in structural molecular biology and molecular design relevant to rational drug discovery. Such approaches focus on the three-dimensional structures of macromolecules and their interactions. In the coming decade such techniques may be applied to a wide variety of diabetes-related targets.

Indexed as

Amino Acid SequenceBinding SitesDiabetes Mellitus, Type 1Drug DesignHumansInsulinMagnetic Resonance SpectroscopyModels, MolecularMolecular Sequence DataPhosphorylasesProtein Structure, SecondaryRecombinant ProteinsSimplexvirusThymidine KinaseX-Ray DiffractionInsulinPhosphorylasesRecombinant ProteinsThymidine Kinase

Identifiers

PMID1335936

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.