ArticleThe Journal of clinical investigation1992
Cyclic adenosine monophosphate prevents the glucocorticoid-mediated inhibition of insulin gene expression in rodent islet cells.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 60 citations in OpenAlex.
- Peroxisome proliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extract and improvement of insulin sensitivity in steroid induced insulin resistant rats.BMC complementary and alternative medicine · 2014Article
- Protein-mediated interactions of pancreatic islet cells.Scientifica · 2013Review
- The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation.Theoretical biology & medical modelling · 2008Article
- Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells.Molecular and cellular biology · 2004Article
- Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance.The Journal of clinical investigation · 2000Article
- Neural cell adhesion molecule (N-CAM) is required for cell type segregation and normal ultrastructure in pancreatic islets.The Journal of cell biology · 1999Article
- Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.The Journal of clinical investigation · 1997Article
- The role of gap junction membrane channels in secretion and hormonal action.Journal of bioenergetics and biomembranes · 1996Review
- Effect of adrenalectomy on the development of a pancreatic islet lesion in fa/fa rats.Diabetologia · 1996Article
- Adequate connexin-mediated coupling is required for proper insulin production.The Journal of cell biology · 1995Article
- Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans.The Journal of clinical investigation · 1993Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dexamethasone negatively regulates insulin gene expression in HIT-15 cells. In vivo, however, an excess of glucocorticoids results in an increase in insulin biosynthesis and peripheral hyperinsulinemia. To resolve this contradiction, we have studied the effects of dexamethasone in primary rat islet cells. We show here that dexamethasone decreases insulin mRNA levels in single islet cells, as in HIT-15 cells, but does not affect these levels in reaggregated islet cells and increases them in intact islets of Langerhans. Because cAMP is an important regulator of insulin gene expression and intracellular cAMP content may be decreased in single beta cells, we investigated whether cAMP could prevent the inhibitory effect of dexamethasone on insulin mRNA levels. In the presence of cAMP analogues, the inhibitory action of dexamethasone was not only prevented, but insulin mRNA increased to levels comparable to those observed when cAMP analogues were used alone. We conclude that the insulin gene is negatively regulated by dexamethasone in single islet cells, but that other factors such as cAMP prevent this effect when the native environment of islet cells is preserved. Our results indicate that insulin gene regulation is influenced by cell to cell contacts within the islet, and that intracellular cAMP levels might be influential in this regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.