ArticleThe Journal of cell biology1992
Mapping of myogenin transcription during embryogenesis using transgenes linked to the myogenin control region.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 76 citations in OpenAlex.
- Dynamics of myogenic differentiation using a novel Myogenin knock-in reporter mouse.Skeletal muscle · 2021Article
- HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors.Frontiers in physiology · 2018Article
- The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion.Developmental biology · 2016Article
- Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3.The Journal of clinical investigation · 2015Article
- A complex RARE is required for the majority of Nedd9 embryonic expression.Transgenic research · 2015Article
- The Cavβ1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells.The Journal of cell biology · 2014Article
- Expression of a dominant negative CELF protein in vivo leads to altered muscle organization, fiber size, and subtype.PloS one · 2011Article
- Nuclear factor kappaB controls acetylcholine receptor clustering at the neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- JAK2/STAT2/STAT3 are required for myogenic differentiation.The Journal of biological chemistry · 2008Article
- Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity.The Journal of clinical investigation · 2007Article
- Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domain.Oncogene · 2007Article
- Regeneration of transgenic skeletal muscles with altered timing of expression of the basic helix-loop-helix muscle regulatory factor MRF4.The American journal of pathology · 2003Article
- Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma.Molecular and cellular biology · 2003Article
- Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Expression of the SM22alpha promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells.The Journal of cell biology · 1996Article
- Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis.Molecular and cellular biology · 1995Article
- Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development.The EMBO journal · 1995Article
- Activation of the myogenin promoter during mouse embryogenesis in the absence of positive autoregulation.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Mouse limb muscle is determined in the absence of the earliest myogenic factor myf-5.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During vertebrate embryogenesis, the muscle-specific helix-loop-helix protein myogenin is expressed in muscle cell precursors in the developing somite myotome and limb bud before muscle fiber formation and is further upregulated during myogenesis. We show that cis-acting DNA sequences within the 5' flanking region of the mouse myogenin gene are sufficient to direct appropriate temporal, spatial, and tissue-specific transcription of myogenin during mouse embryogenesis. Myogenin-lacZ transgenes trace the fate of embryonic cells that activate myogenin transcription and suggest that myogenic precursor cells that migrate from the somite myotome to the limb bud are committed to a myogenic fate in the absence of myogenin transcription. Activation of a myogenin-lacZ transgene can occur in limb bud explants in culture, indicating that signals required for activation of myogenin transcription are intrinsic to the limb bud and independent of other parts of the embryo. These results reveal multiple populations of myogenic precursor cells during development and suggest the existence of regulators other than myogenic helix-loop-helix proteins that maintain cells in the early limb bud in the myogenic lineage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.