ArticleThe Journal of cell biology1992
Protein kinase C activation antagonizes melatonin-induced pigment aggregation in Xenopus laevis melanophores.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 59 citations in OpenAlex.
- 5-HT receptors as novel targets for optimizing pigmentary responses in dorsal skin melanophores of frog, Hoplobatrachus tigerinus.British journal of pharmacology · 2012Article
- The protein kinase A-anchoring protein moesin is bound to pigment granules in melanophores.Traffic (Copenhagen, Denmark) · 2009Article
- Carbachol-mediated pigment granule dispersion in retinal pigment epithelium requires Ca2+ and calcineurin.BMC cell biology · 2007Article
- Rhabdomeric phototransduction initiated by the vertebrate photopigment melanopsin.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- An endogenous 5-HT(7) receptor mediates pigment granule dispersion in Xenopus laevis melanophores.British journal of pharmacology · 2001Article
- Dynein, dynactin, and kinesin II's interaction with microtubules is regulated during bidirectional organelle transport.The Journal of cell biology · 2000Article
- Regulation of organelle movement in melanophores by protein kinase A (PKA), protein kinase C (PKC), and protein phosphatase 2A (PP2A).The Journal of cell biology · 1998Article
- A new form of inherited red-blindness identified in zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- A rapid bioassay for platelet-derived growth factor beta-receptor tyrosine kinase function.Bio/technology (Nature Publishing Company) · 1994Article
- Characterization of a serotonin receptor endogenous to frog melanophores.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pineal hormone, melatonin (5-methoxy N-acetyltryptamine) induces a rapid aggregation of melanin-containing pigment granules in isolated melanophores of Xenopus laevis. Treatment of melanophores with activators of protein kinase C (PKC), including phorbol esters, mezerein and a synthetic diacylglycerol, did not affect pigment granule distribution but did prevent and reverse melatonin-induced pigment aggregation. This effect was blocked by an inhibitor of PKC, Ro 31-8220. The inhibitory effect was not a direct effect on melatonin receptors, per se, as the slow aggregation induced by a high concentration of an inhibitor of cyclic AMP-dependent protein kinase (PKA), adenosine 3',5'-cyclic monophosphothioate, Rp-diastereomer (Rp-cAMPS), was also reversed by PKC activation. Presumably activation of PKC, like PKA activation, stimulates the intracellular machinery involved in the centrifugal translocation of pigment granules along microtubules. alpha-Melanocyte stimulating hormone (alpha-MSH), like PKC activators, overcame melatonin-induced aggregation but this response was not blocked by the PKC inhibitor, Ro 31-8220. This data indicates that centrifugal translocation (dispersion) of pigment granules in Xenopus melanophores can be triggered by activation of either PKA, as occurs after alpha-MSH treatment, or PKC. The very slow aggregation in response to inhibition of PKA with high concentrations of Rp-cAMPS, suggests that the rapid aggregation in response to melatonin may involve multiple intracellular signals in addition to the documented Gi-mediated inhibition of adenylate cyclase.
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