ArticleThe EMBO journal1992
Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.
Article in The EMBO journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- T cell clonality assessment: past, present and future.Journal of clinical pathology · 2018Review
- ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.Molecular and cellular biology · 2015Article
- Article
- Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- ABI-like transcription factor gene TaABL1 from wheat improves multiple abiotic stress tolerances in transgenic plants.Functional & integrative genomics · 2014Article
- The soybean GmbZIP1 transcription factor enhances multiple abiotic stress tolerances in transgenic plants.Plant molecular biology · 2011Article
- The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.PloS one · 2011Article
- The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.Blood · 2005Article
- Loss of adenomatous polyposis coli gene function disrupts thymic development.Nature immunology · 2005Article
- The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.Oncogene · 2004Review
- Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.The Journal of experimental medicine · 2004Article
- Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk.The Journal of experimental medicine · 2003Article
- Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1.The EMBO journal · 2002Article
- Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).The Journal of experimental medicine · 2001Article
- Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.Molecular and cellular biology · 2001Article
- Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.The EMBO journal · 2000Article
- Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions.The Journal of experimental medicine · 2000Article
- Massive apoptosis of thymocytes in T-cell-deficient Id1 transgenic mice.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The variable region genes of the T cell receptor (TCR) alpha and beta chains are assembled by somatic recombination of separate germline elements. During thymocyte development, gene rearrangements display both an ordered progression, with beta chain formation preceding alpha chain, and allelic exclusion, with each cell containing a single functional beta chain rearrangement. Although considerable evidence supports the view that the individual loci are regulated independently, signaling molecules that may participate in controlling TCR gene recombination remain unidentified. Here we report that the lymphocyte-specific protein tyrosine kinase p56lck, when overexpressed in developing thymocytes, provokes a reduction in V beta--D beta rearrangement while permitting normal juxtaposition of other TCR gene segments. Our data support a model in which p56lck activity impinges upon a signaling process that ordinarily permits allelic exclusion at the beta-chain locus.
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