ArticleProceedings of the National Academy of Sciences of the United States of America1992
NIP1, a gene required for nuclear transport in yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Enhanced mitochondrial degradation of yeast cytochrome c with amphipathic structures.Current genetics · 2005Article
- Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.Molecular and cellular biology · 2004Article
- Gene expression of TPA induced differentiation in HL-60 cells by DNA microarray analysis.Nucleic acids research · 2002Article
- Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome.Molecular biology of the cell · 2002Article
- Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo.Molecular and cellular biology · 2000Article
- A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing.Molecular and cellular biology · 1999Article
- Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5.Molecular and cellular biology · 1998Article
- Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis.Molecular and cellular biology · 1997Article
- Nuclear localization signal binding proteins in higher plant nuclei.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Reconstitution of nuclear protein transport with semi-intact yeast cells.The Journal of cell biology · 1993Article
- Specific binding of nuclear localization sequences to plant nuclei.The Plant cell · 1993Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Cytochrome c with a nuclear localization signal added at the N terminus was mistargeted to the nucleus, resulting in a yeast strain deficient in mitochondrial cytochrome c. Reversion of this strain allowed the isolation of temperature-conditional mutants defective in nuclear transport, as demonstrated with one of these mutants, nip1-1, that was shown to be defective in nuclear accumulation of a LacZ protein containing a nuclear localization signal of the yeast ribosomal protein L29. The NIP1+ gene was cloned and shown to encode a 93,143-Da protein. Furthermore, an epitope-labeled NIP1 protein migrated in SDS/polyacrylamide gels with a mass of approximately 100,000 Da and was shown by immunofluorescence to localize mainly in the cytoplasm. NIP1+ was shown to be an essential gene by gene disruption experiments. Intriguingly, NIP1 has a serine-rich acidic N-terminal region that is similar in this regard to the N-terminal region of a previously described nuclear localization signal-binding protein, NSR1.
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