ArticleThe New England journal of medicine1992
Expression of Epstein-Barr virus-encoded small RNA (by the EBER-1 gene) in liver specimens from transplant recipients with post-transplantation lymphoproliferative disease.
Article in The New England journal of medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 213 citations in OpenAlex.
- Epstein-Barr virus infection-associated cholangiocarcinoma: a report of one case and the review of literature.Virology journal · 2022Review
- Virus-Driven Carcinogenesis.Cancers · 2021Review
- Development of lymphoma from the donor of haploidentical stem cell transplantation: A case report.Molecular and clinical oncology · 2017Article
- The Impact of EBV Status on Characteristics and Outcomes of Posttransplantation Lymphoproliferative Disorder.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2015Article
- Lung transplantation for cystic fibrosis: results, indications, complications, and controversies.Seminars in respiratory and critical care medicine · 2015Review
- Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases.Cancer science · 2012Article
- Epstein-Barr-Virus-Positive B-Cell Lymphoma of Recipient Origin Despite of the Elimination of Clonally EBV-Infected T Cells by Allogeneic Stem Cell Transplantation in a Patient with Chronic Active EBV Infection.Case reports in transplantation · 2012Article
- Infectious diseases and the liver.Clinics in liver disease · 2011Review
- Pediatric post-transplant lymphoproliferative disorder after cardiac transplantation.International journal of hematology · 2009Review
- Avoiding pitfalls: what an endoscopist should know in liver transplantation--part II.Digestive diseases and sciences · 2009Review
- Recent advances in the diagnosis and therapy of Richter's syndrome.Medical oncology (Northwood, London, England) · 2007Review
- Posttransplant lymphoproliferative disorders in liver transplantation: a 20-year experience.Annals of surgery · 2002Article
- Epstein-Barr virus infection in transplant recipients: Summary of a workshop on surveillance, prevention and treatment.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 2002Article
- Epstein-Barr virus infection in paediatric liver transplant recipients: detection of the virus in post-transplant tonsillectomy specimens.Molecular pathology : MP · 2001Article
- Detection of Epstein-Barr virus DNA in sera from transplant recipients with lymphoproliferative disorders.Journal of clinical microbiology · 1999Article
- Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay.Journal of clinical microbiology · 1999Article
- The antiviral prophylaxis of post-transplant lymphoproliferative disorder.Springer seminars in immunopathology · 1998Review
- The molecular genetics of post-transplantation lymphoproliferative disorders.Springer seminars in immunopathology · 1998Review
- Clinical and pathological features of post-transplant lymphoproliferative disorders (PTLD).Springer seminars in immunopathology · 1998Review
- Epstein-Barr virus, infectious mononucleosis, and posttransplant lymphoproliferative disorders.Transplantation science · 1994Review
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7 authors at 3 institutions in 1 country.
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Abstract
backgroundEpstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disease (PTLD) develops in 1 to 10 percent of transplant recipients, in whom it can be treated by a reduction in the level of immunosuppression. We postulated that the tissue expression of the small RNA transcribed by the EBER-1 gene during latent EBV infection would identify patients at risk for PTLD.
methodsWe studied EBER-1 gene expression in liver specimens obtained from 24 patients 2 days to 22 months before the development of PTLD, using in situ hybridization with an oligonucleotide probe. Control specimens were obtained from 20 recipients of allografts with signs of injury due to organ retrieval, acute graft rejection, or viral hepatitis in whom PTLD had not developed 9 to 71 months after the biopsy.
resultsOf the 24 patients with PTLD, 17 (71 percent) had specimens in which 1 to 40 percent of mononuclear cells were positive for the EBER-1 gene. In addition, 10 of these 17 patients (59 percent) had specimens with histopathological changes suggestive of EBV hepatitis. In every case, EBER-1-positive cells were found within the lymphoproliferative lesions identified at autopsy. Only 2 of the 20 controls (10 percent) had specimens with EBER-1-positive cells (P < 0.001), and such cells were rare.
conclusionsEBER-1 gene expression in liver tissue precedes the occurrence of clinical and histologic PTLD. The possibility of identifying patients at risk by the method we describe here and preventing the occurrence of PTLD by a timely reduction of immunosuppression needs to be addressed by future prospective studies.
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