ArticleJournal of virology1992
A mouse mammary tumor virus mammary gland enhancer confers tissue-specific but not lactation-dependent expression in transgenic mice.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Transactivation of the novel 5' cis-acting element of mouse mammary tumor virus (MMTV) by human retroviral transactivators Tat and Tax.Communications biology · 2024Article
- Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue.Viruses · 2022Review
- Regulation of Expression and Latency in BLV and HTLV.Viruses · 2020Review
- MMTV does not encode viral microRNAs but alters the levels of cancer-associated host microRNAs.Virology · 2018Article
- MMTV infectious cycle and the contribution of virus-encoded proteins to transformation of mammary tissue.Journal of mammary gland biology and neoplasia · 2008Review
- A 5' distal palindrome within the mouse mammary tumor virus-long terminal repeat recruits a mammary gland-specific complex and is required for a synergistic response to progesterone plus prolactin.Journal of molecular endocrinology · 2008Article
- Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages.Molecular oncology · 2007Article
- Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis.The American journal of pathology · 2005Article
- CDP is a repressor of mouse mammary tumor virus expression in the mammary gland.Journal of virology · 2000Article
- Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation.Molecular and cellular biology · 1999Article
- Mammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat.Journal of virology · 1999Article
- Expression of ovine insulin-like growth factor-1 (IGF-1) stimulates alveolar bud development in mammary glands of transgenic mice.Endocrine · 1998Article
- Construction and characterization of a hybrid mouse mammary tumor virus/murine leukemia virus-based retroviral vector.Journal of virology · 1998Article
- Generation of a tumorigenic milk-borne mouse mammary tumor virus by recombination between endogenous and exogenous viruses.Journal of virology · 1997Article
- A redundant nuclear protein binding site contributes to negative regulation of the mouse mammary tumor virus long terminal repeat.Journal of virology · 1995Article
- Tissue-specific and ubiquitous factors binding next to the glucocorticoid receptor modulate transcription from the mouse mammary tumor virus promoter.Journal of virology · 1995Article
- Nucleoprotein structure influences the response of the mouse mammary tumor virus promoter to activation of the cyclic AMP signalling pathway.Molecular and cellular biology · 1995Article
- Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range.Journal of virology · 1994Article
- Stably integrated mouse mammary tumor virus long terminal repeat DNA requires the octamer motifs for basal promoter activity.Molecular and cellular biology · 1994Article
- Functional redundancy of octamer elements in the mouse mammary tumor virus promoter.Nucleic acids research · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The long terminal repeat (LTR) of mouse mammary tumor virus (MMTV) is known to contain a number of transcriptional regulatory elements, including glucocorticoid response elements. In this study, we showed that a mammary gland/salivary gland enhancer found in the LTR of this virus directs expression of a heterologous promoter to both virgin and lactating mammary glands in transgenic mice. Using transgenic mice containing hybrid gene constructs with various deletions of the LTR sequences linked to marker genes, we also showed that the dramatic increase in MMTV expression that occurs during lactation is due to the glucocorticoid response elements. Thus, the MMTV LTR encodes two distinct elements, both of which are required for a high level of expression in lactating mammary glands.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.