ArticleThe Journal of clinical investigation1992
Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.
Article in The Journal of clinical investigation, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 214 citations in OpenAlex.
- Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U-87 MG cells.FEBS open bio · 2026Article
- Article
- Amylin, Another Important Neuroendocrine Hormone for the Treatment of Diabesity.International journal of molecular sciences · 2024Review
- Islet amyloid polypeptide does not suppress pancreatic cancer.Molecular metabolism · 2023Article
- CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons.Frontiers in physiology · 2022Article
- Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study.Journal of dental sciences · 2022Article
- Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases.Molecular metabolism · 2021Review
- SWI/SNF Complex Mutations in Gynecologic Cancers: Molecular Mechanisms and Models.Annual review of pathology · 2020Review
- Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma.Therapeutic advances in medical oncology · 2020Review
- The Importance of Understanding Amylin Signaling Mechanisms for Therapeutic Development in the Treatment of Alzheimer's Disease.Current pharmaceutical design · 2020Review
- Effects of Salmon Calcitonin on the Concentrations of Monoamines in Periaqueductal Gray in Formalin TestBalkan medical journal · 2019Article
- Article
- Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development.British journal of pharmacology · 2016Review
- Consequences of splice variation on Secretin family G protein-coupled receptor function.British journal of pharmacology · 2012Review
- Identification of the calcitonin receptor in osteoarthritic chondrocytes.BMC research notes · 2011Article
- Interactive effect of fluoride burden with calcitonin receptor gene polymorphisms on the risk of F bone injury.International archives of occupational and environmental health · 2011Article
- Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentration.Journal of the American Society of Nephrology : JASN · 2011Article
- Calcitonin and calcitonin receptors.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2007Article
- The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling.Molecular endocrinology (Baltimore, Md.) · 2005Article
- Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.The American journal of pathology · 1998Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
A human ovarian small cell carcinoma line (BIN-67) expresses abundant calcitonin (CT) receptors (CTR) (143,000 per cell) that are coupled, to adenylate cyclase. The dissociation constants (Kd) for the CTRs on these BIN-67 cells is approximately 0.42 nM for salmon CT and approximately 4.6 nM for human CT. To clone a human CTR (hCTR), a BIN-67 cDNA library was screened using a cDNA probe from a porcine renal CTR (pCTR) that we recently cloned. One positive clone of 3,588 bp was identified. Transfection of this cDNA into COS cells resulted in expression of receptors with high affinity for salmon CT (Kd = approximately 0.44 nM) and for human CT (Kd = approximately 5.4 nM). The expressed hCTR was coupled to adenylate cyclase. Northern analysis with the hCTR cDNA probe indicated a single transcript of approximately 4.2 kb. The cloned cDNA encodes a putative peptide of 490 amino acids with seven potential transmembrane domains. The amino acid sequence of the hCTR is 73% identical to the pCTR, although the hCTR contains an insert of 16 amino acids between transmembrane domain I and II. The structural differences may account for observed differences in binding affinity between the porcine renal and human ovarian CTRs. The CTRs are closely related to the receptors for parathyroid hormone-parathyroid hormone-related peptide and secretin; these receptors comprise a distinct family of G protein-coupled seven transmembrane domain receptors. Interestingly, the hCTR sequence is remotely related to the cAMP receptor of Dictyostelium discoideum (21% identical), but is not significantly related to other G protein-coupled receptor sequences now in the data bases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.