ArticleMolecular and cellular biology1992
Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogenin.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients.Trends in molecular medicine · 2024Review
- (Epi)genetic Modifications in Myogenic Stem Cells: From Novel Insights to Therapeutic Perspectives.Cells · 2019Review
- Dietary tributyrin, an HDAC inhibitor, promotes muscle growth through enhanced terminal differentiation of satellite cells.Physiological reports · 2018Article
- Effects of myogenin on expression of late muscle genes through MyoD-dependent chromatin remodeling ability of myogenin.Molecules and cells · 2012Article
- Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- Article
- Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program.The EMBO journal · 2001Article
- Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB.Molecular and cellular biology · 1998Article
- Nuclear matrix, dynamic histone acetylation and transcriptionally active chromatin.Molecular biology reports · 1997Review
- Selection for retroviral insertions into regulated genes.Journal of virology · 1997Article
- Expression of the Gs protein alpha-subunit disrupts the normal program of differentiation in cultured murine myogenic cells.The Journal of clinical investigation · 1997Article
- Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum.The Plant cell · 1995Article
- Histone acetylation: facts and questions.Chromosoma · 1994Review
- Feedback control of gene expression.Photosynthesis research · 1994Article
- Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sodium butyrate reversibly inhibits muscle differentiation and blocks the expression of many muscle-specific genes in both proliferating myoblasts and differentiated myotubes. We investigated the role of the basic helix-loop-helix (bHLH) myogenic determinator proteins MyoD and myogenin in this inhibition. Our data suggest that both MyoD and myogenin are not able to function as transcriptional activators in the presence of butyrate, although both apparently retain the ability to bind DNA. Transcription of MyoD itself is extinguished in butyrate-treated myoblasts and myotubes, an effect that may be due to the inability of MyoD to autoactivate its own transcription. We present evidence that the HLH region of MyoD is essential for butyrate inhibition of MyoD. In contrast to MyoD and myogenin, butyrate does not inhibit the ubiquitous basic HLH protein E2-5 from functioning as a transcriptional activator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.