ArticleMolecular and cellular biology1992
A novel myoblast enhancer element mediates MyoD transcription.
Article in Molecular and cellular biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 128 citations in OpenAlex.
- Developmental expression of the skeletal muscle determination gene,bioRxiv : the preprint server for biology · 2026Article
- Augmenting and directing long-range CRISPR-mediated activation in human cells.Nature methods · 2021Article
- The SNPs in myoD gene from normal muscle developing individuals have no effect on muscle mass.BMC genetics · 2019Article
- Master control: transcriptional regulation of mammalian Myod.Journal of muscle research and cell motility · 2019Review
- MUNC, an Enhancer RNA Upstream from theMolecular and cellular biology · 2018Article
- A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.Molecular cell · 2018Article
- MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation.Nucleic acids research · 2017Article
- Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Association of lamin A/C with muscle gene-specific promoters in myoblasts.Biochemistry and biophysics reports · 2015Article
- Expression of myogenic regulatory factors in chicken embryos during somite and limb development.Journal of anatomy · 2015Article
- Tissue-specific epigenetics in gene neighborhoods: myogenic transcription factor genes.Human molecular genetics · 2015Article
- Wnt3a signal pathways activate MyoD expression by targeting cis-elements inside and outside its distal enhancer.Bioscience reports · 2015Article
- MUNC, a long noncoding RNA that facilitates the function of MyoD in skeletal myogenesis.Molecular and cellular biology · 2015Article
- STAT3 signaling controls satellite cell expansion and skeletal muscle repair.Nature medicine · 2014Article
- Long noncoding RNAs, emerging players in muscle differentiation and disease.Skeletal muscle · 2014Article
- eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci.Molecular cell · 2013Article
- Article
- Stepwise acetyltransferase association and histone acetylation at the Myod1 locus during myogenic differentiation.Scientific reports · 2013Article
- Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration.The Journal of cell biology · 2012Article
- Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis.Development (Cambridge, England) · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MyoD gene can orchestrate the expression of the skeletal muscle differentiation program. We have identified the regions of the gene necessary to reproduce transcription specific to skeletal myoblasts and myotubes. A proximal regulatory region (PRR) contains a conserved TATA box, a CCAAT box, and a GC-rich region that includes a consensus SP1 binding site. The PRR is sufficient for high levels of skeletal muscle-specific activity in avian muscle cells. In murine cells the PRR alone has only low levels of activity and requires an additional distal regulatory region to achieve high levels of muscle-specific activity. The distal regulatory region differs from a conventional enhancer in that chromosomal integration appears necessary for productive interactions with the PRR. While the Moloney leukemia virus long terminal repeat can enhance transcription from the MyoD PRR in both transient and stable assays, the simian virus 40 enhancer cannot, suggesting that specific enhancer-promoter interactions are necessary for PRR function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.